Nrf2 in health and disease: current and future clinical implications

被引：115
作者：
Al-Sawaf, Othman [1 ]
Clarner, Tim [2 ]
Fragoulis, Athanassios [3 ]
Kan, Yuet Wai [4 ]
Pufe, Thomas [1 ]
Streetz, Konrad [5 ]
Wruck, Christoph Jan [1 ]
机构：
[1] Rhein Westfal TH Aachen, Univ Hosp, Dept Anat & Cell Biol, Aachen, Germany
[2] Rhein Westfal TH Aachen, Univ Hosp, Inst Neuroanat, Aachen, Germany
[3] Rhein Westfal TH Aachen, Univ Hosp, Dept Orthopaed Surg, Aachen, Germany
[4] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94115 USA
[5] Univ Hosp RWTH Aachen, Dept Internal Med Gastroenterol & Metab Disorders, Aachen, Germany
来源：
CLINICAL SCIENCE | 2015年 / 129卷 / 12期
关键词：
cardiovascular disease; chronic kidney disease; clinical trials; multiple sclerosis; Nrf2; oxidative stress; CHRONIC KIDNEY-DISEASE; ERYTHROID 2-RELATED FACTOR-2; TRANSCRIPTION FACTOR NRF2; TYPE-2; DIABETES-MELLITUS; NF-KAPPA-B; BARDOXOLONE METHYL EVALUATION; ANTIOXIDANT RESPONSE ELEMENT; REMITTING MULTIPLE-SCLEROSIS; PLACEBO-CONTROLLED PHASE-3; OXIDATIVE STRESS;
D O I：
10.1042/CS20150436
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large battery of cytoprotective genes, it plays a crucial role in the prevention of degenerative disease in multiple organs. Thus it has been the focus of research as a pharmacological target that could be used for prevention and treatment of chronic diseases such as multiple sclerosis, chronic kidney disease or cardiovascular diseases. The present review summarizes promising findings from basic research and shows which Nrf2-targeting therapies are currently being investigated in clinical trials and which agents have already entered clinical practice.
引用
收藏
页码：989 / 999
页数：11
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