The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large battery of cytoprotective genes, it plays a crucial role in the prevention of degenerative disease in multiple organs. Thus it has been the focus of research as a pharmacological target that could be used for prevention and treatment of chronic diseases such as multiple sclerosis, chronic kidney disease or cardiovascular diseases. The present review summarizes promising findings from basic research and shows which Nrf2-targeting therapies are currently being investigated in clinical trials and which agents have already entered clinical practice.
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Adair-Kirk, Tracy L.
;
Atkinson, Jeffrey J.
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Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Atkinson, Jeffrey J.
;
Griffin, Gail L.
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Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Griffin, Gail L.
;
Watson, Mark A.
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Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Watson, Mark A.
;
Kelley, Diane G.
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Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Kelley, Diane G.
;
DeMello, Daphne
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Phoenix Childrens Hosp, Dept Pathol, Phoenix, AZ USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
DeMello, Daphne
;
Senior, Robert M.
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机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Senior, Robert M.
;
Betsuyaku, Tomoko
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Hokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Azarenko, Olga
;
Okouneva, Tatiana
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Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Okouneva, Tatiana
;
Singletary, Keith W.
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机构:
Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Singletary, Keith W.
;
Jordan, Mary Ann
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Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Jordan, Mary Ann
;
Wilson, Leslie
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Adair-Kirk, Tracy L.
;
Atkinson, Jeffrey J.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Atkinson, Jeffrey J.
;
Griffin, Gail L.
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Griffin, Gail L.
;
Watson, Mark A.
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Watson, Mark A.
;
Kelley, Diane G.
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Kelley, Diane G.
;
DeMello, Daphne
论文数: 0引用数: 0
h-index: 0
机构:
Phoenix Childrens Hosp, Dept Pathol, Phoenix, AZ USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
DeMello, Daphne
;
Senior, Robert M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
Senior, Robert M.
;
Betsuyaku, Tomoko
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Med 1, Sapporo, Hokkaido 0608638, Japan
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Azarenko, Olga
;
Okouneva, Tatiana
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Okouneva, Tatiana
;
Singletary, Keith W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Singletary, Keith W.
;
Jordan, Mary Ann
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Jordan, Mary Ann
;
Wilson, Leslie
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h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA