Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

被引:25
作者
Forouzanfar, Fatemeh [1 ,2 ]
Barreto, George [3 ,4 ]
Majeed, Muhammed [5 ,6 ]
Sahebkar, Amirhossein [7 ,8 ,9 ]
机构
[1] Mashhad Univ Med Sci, Neurosci Res Ctr, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Fac Med, Dept Neurosci, Mashhad, Razavi Khorasan, Iran
[3] Pontificia Univ Javeriana, Fac Ciencias, Dept Nutr & Bioquim, Bogota, DC, Colombia
[4] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile
[5] Sabinsa Corp, East Windsor, NJ USA
[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran
[7] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran
[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran
[9] Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran
关键词
cancer; curcumin; heat shock protein; herbal medicine; FATTY LIVER-DISEASE; SYSTEMIC OXIDATIVE STRESS; TYPE-2; DIABETES-MELLITUS; HSP70; GENE-EXPRESSION; HEPATOCELLULAR-CARCINOMA; PIPERINE COMBINATION; CLINICAL-PRACTICE; CELLS; APOPTOSIS; ANALOG;
D O I
10.1002/biof.1522
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.
引用
收藏
页码:631 / 640
页数:10
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