COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy

被引：39

作者：

Novelli, Giuseppe ^{[1
,2
,3
]}

Biancolella, Michela ^{[4
]}

Mehrian-Shai, Ruty ^{[5
]}

Colona, Vito Luigi ^{[1
]}

Brito, Anderson F. ^{[6
]}

Grubaugh, Nathan D. ^{[6
]}

Vasiliou, Vasilis ^{[7
]}

Luzzatto, Lucio ^{[8
]}

Reichardt, Juergen K. V. ^{[9
]}

机构：

[1] Tor Vergata Univ Rome, Dept Biomed & Prevent, I-00133 Rome, Italy

[2] IRCCS Neuromed, Pozzilli, IS, Italy

[3] Univ Nevada, Sch Med, Dept Pharmacol, Reno, NV 89557 USA

[4] Tor Vergata Univ Rome, Dept Biol, I-00133 Rome, Italy

[5] Sheba Med Ctr, Pediat Hematooncol, Tel Hashomer, Israel

[6] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06510 USA

[7] Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06510 USA

[8] Muhimbili Univ Hlth & Allied Sci, Haematol, Dar Es Salaam, Tanzania

[9] James Cook Univ, Australian Inst Trop Hlth & Med, Smithfield, Qld 4878, Australia

来源：

HUMAN GENOMICS | 2021年 / 15卷 / 01期

关键词：

Coronavirus; SARS-CoV-2; COVID-19; Pandemic; Variants; Vaccines; Monoclonal antibodies; Politics; HUMAN MONOCLONAL-ANTIBODY; SARS CORONAVIRUS; VARIANTS; ACE2; SUSCEPTIBILITY; INSIGHTS; PROTEIN; NEUTRALIZATION; RESISTANCE; INFECTION;

D O I：

10.1186/s40246-021-00326-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents.

引用

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