Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry

被引：11

作者：

Pang, GF ^{[1
]}

Cao, YZ

Fan, CL

Zhang, JJ

Li, XM

Wang, C

机构：

[1] Qinhuangdao Import & Export Commod Inspect Bur, Qinhuangdao 066002, PC, Peoples R China

[2] China Import & Export Commod Inspect Inst, Beijing 100025, PC, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 882卷 / 1-2期

关键词：

meat; food analysis; clopidol;

D O I：

10.1016/S0021-9673(00)00436-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-performance liquid chromatographic-mass spectrometric (HPLC-MS) method has been developed for determination of clopidol residues in chicken tissues. Samples are extracted with acetonitrile. The extracts are cleaned up on an alumina column followed by an anion-exchange column. The clopidol is separated on a column (150 cmx4.6 mm) of Intertsil by using acetonitrile-water (20:80) as mobile phase. The clopidol was qualitatively identified by molecule mass and determined quantitatively by selected ion monitoring mode at 190 m/z. The recoveries with RSDs ranged from 91.6+/-10.1 to 97.3+/-5.7 at 0.010 to 10.0 mg/kg by spiking three matrices (chicken muscle, liver, and kidney). The limit of detection was 0.005 mg/kg, and the limit of quantification was 0.010 mg/kg. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：85 / 88

页数：4