Polymeric Materials and Formulation Technologies for Modified-Release Tablet Development

被引：6

作者：

Zarate, J. ^{[1
,2
]}

Igartua, M. ^{[1
,2
]}

Hernandez, R. M. ^{[1
,2
]}

Pedraz, J. L. ^{[1
,2
]}

机构：

[1] Univ Basque Country, Lab Pharm & Pharmaceut Technol, Fac Pharm, Vitoria 01006, Spain

[2] SLFPB EHU, Networking Biomed Res Ctr Bioengn Biomat & Nanome, CIBER BBN, Vitoria 01006, Spain

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 13期

关键词：

Matrix tablets; modified-release; controlled-release; extended-release; multilayer; coating; zero-order; natural polymers; HYDROPHILIC MATRIX TABLETS; ORAL CONTROLLED DELIVERY; POROSITY OSMOTIC PUMP; WATER-INSOLUBLE DRUG; EXTENDED-RELEASE; IN-VITRO; INTERPOLYMER COMPLEXES; CHITOSAN; SYSTEM; DESIGN;

D O I：

10.2174/138955709790361539

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Over the last years significant advances have been made in the area of drug delivery with the development of modified-release (MR) dosage forms. The present review is divided into two parts, one dealing with technologies for the design of modified-release drug delivery tablets and the other with the use of synthetic and natural polymers that are capable of controlling drug release.

引用

页码：1504 / 1517

页数：14

共 96 条

[1] Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer [J].