Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis

被引：24

作者：

Gandini, Sara ^{[1
]}

Zanna, Ines ^{[2
]}

Angelis, Simone Pietro De ^{[1
]}

Cocorocchio, Emilia ^{[3
]}

Queirolo, Paola ^{[3
]}

Lee, Jenny H. ^{[4
]}

Carlino, Matteo S. ^{[5
,6
]}

Mazzarella, Luca ^{[1
]}

Duso, Bruno Achutti ^{[1
]}

Palli, Domenico ^{[2
]}

Raimondi, Sara ^{[1
]}

Caini, Saverio ^{[2
]}

机构：

[1] IRCCS, European Inst Oncol IEO, Mol & Pharmacoepidemiol Unit, Dept Expt Oncol, Milan, Italy

[2] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Lifestyle Epidemiol Unit, Via Cosimo il Vecchio 2, I-50141 Florence, Italy

[3] IRCCS, European Inst Oncol IEO, Div Med Oncol Melanoma Sarcoma & Rare Tumors, Milan, Italy

[4] Macquarie Univ, Dept Clin Med, Sydney, NSW, Australia

[5] Westmead & Blacktown Hosp, Melanoma Inst Australia, Dept Clin Oncol, Sydney, NSW, Australia

[6] Univ Sydney, Sydney, NSW, Australia

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 157卷

关键词：

Melanoma; Survival; Circulating tumour DNA; Review; Meta-analysis; BRAF(V600E) MUTATION; CLINICAL-SIGNIFICANCE; METASTATIC MELANOMA; PREDICTS SURVIVAL; BRAF MUTATIONS; DIGITAL PCR; ANTIBODIES; INHIBITORS; PLASMA; CANCER;

D O I：

10.1016/j.critrevonc.2020.103187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We reviewed and meta-analysed the available evidence (until December 2019) about circulating tumour DNA (ctDNA) levels and melanoma patients survival. We included twenty-six studies (>2000 patients overall), which included mostly stage III-IV cutaneous melanoma patients and differed widely in terms of systemic therapy received and somatic mutations that were searched. Patients with detectable ctDNA before treatment had worse progression-free survival (PFS) (summary hazard ratio (SHR) 2.47, 95 % confidence intervals (CI) 1.85-3.29) and overall survival (OS) (SHR 2.98, 95 % CI 2.26-3.92), with no difference by tumour stage. ctDNA detectability during follow-up was associated with poorer PFS (SHR 4.27, 95 %CI 2.75-6.63) and OS (SHR 3.91, 95 %CI 1.97-7.78); in the latter case, the association was stronger (p = 0.01) for stage IV vs. III melanomas. Betweenestimates heterogeneity was low for all pooled estimates. ctDNA is a strong prognostic biomarker for advancedstage melanoma patients, robust across tumour (e.g. genomic profile) and patients (e.g. systemic therapy) characteristics.

引用

页数：8

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