ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory

被引：58

作者：

Medina, Jorge H. ^{[1
]}

Viola, Haydee ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, IBCN Dr Eduardo De Robertis, CONICET, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular Dr Hector Maldonad, Buenos Aires, DF, Argentina

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷

关键词：

ERK1/2; long-term memory; retrieval; reconsolidation; extinction; durability; LONG-TERM-MEMORY; SIGNAL-REGULATED KINASE; SYNAPTIC PLASTICITY; PROTEIN-SYNTHESIS; GLUTAMATE RECEPTORS; RAT HIPPOCAMPUS; FEAR MEMORIES; MAPK CASCADE; ACTIVATION; CONSOLIDATION;

D O I：

10.3389/fnmol.2018.00361

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.

引用

页数：8

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