Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys

被引:10
作者
Chong, Ka Chun [1 ,2 ]
Rui, Yan [3 ]
Liu, Yan [1 ]
Zhou, Tianyuan [1 ]
Jia, Katherine [1 ]
Wang, Maggie Haitian [1 ,2 ]
Mohammad, Kirran N. [1 ]
He, Hanqing [3 ]
机构
[1] Chinese Univ Hong Kong, Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Shenzhen Res Inst, Clin Trials & Biostat Lab, Shenzhen 518172, Peoples R China
[3] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310058, Peoples R China
基金
中国国家自然科学基金;
关键词
measles; infants; China; MV; serosurvey; maternal; waning; vaccine; VACCINATION; ELIMINATION; OUTBREAK; TIMELINESS; MORTALITY; CAMPAIGN; CHILDREN;
D O I
10.3390/ijerph16234680
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women.
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页数:8
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