Traumatic brain injury-research and expression of caveolin-1 and its relationship with disease prognosis

被引：2

作者：

Wang, Xiangdong ^{[1
]}

Ren, Xinliang ^{[1
]}

Wang, Yanhong ^{[1
]}

Li, Jianhong ^{[1
]}

Guo, Tiezhu ^{[1
]}

Li, Fan ^{[1
]}

Zhao, Zhiqiang ^{[1
]}

机构：

[1] Changzhi Med Coll, Heji Hosp, Dept Neurosurg, Changzhi City, Shanxi Province, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 30卷 / 03期

关键词：

Brain injury; caveolin-1; expression; prognosis; HEMORRHAGE; BIOLOGY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this paper is to study the expression of caveolin-1 in the traumatic brain injury patients and its relationship with disease prognosis. Caveolin-1 was measured in 52 patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 week after onset by enzyme-linked immunosorbent assay (ELISA), to observe the changes of cerebrospinal fluid caveolin-1. The level of caveolin-1 in the brain of patients was higher than that of the control group at 8 h, 24h, 48 h, 72h and 1 weeks after the onset (P<0.05) and the level of caveolin-1 in cerebrospinal fluid (CSF) of the severe group was higher than that of the light-medium group within 8h, 24h, 48 h and 72h after the onset (P<0.05). The level of caveolin-1 in CSF was significantly increased in patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 weeks after onset, and the expression of caveolin-1 in brain was related to the severity of craniocerebral injury. Therefore, the expression of caveolin-1 can be used as an indicator of the prognosis of traumatic brain injury disease.

引用

页码：997 / 1000

页数：4

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