High stathmin expression is a marker for poor clinical outcome in endometrial cancer: An NRG oncology group/gynecologic oncology group study

被引：23

作者：

Reyes, Henry D. ^{[1
]}

Miecznikowski, Jeffrey ^{[2
]}

Gonzalez-Bosquet, Jesus ^{[1
]}

Devor, Eric J. ^{[1
]}

Zhang, Yuping ^{[1
]}

Thiel, Kristina W. ^{[1
]}

Samuelson, Megan I. ^{[3
]}

McDonald, Megan ^{[1
]}

Stephan, Jean-Marie ^{[1
]}

Hanjani, Parviz ^{[4
]}

Guntupalli, Saketh ^{[5
]}

Tewari, Krishnansu S. ^{[6
]}

Backes, Floor ^{[7
]}

Ramirez, Nilsa ^{[8
]}

Fleming, Gini F. ^{[9
]}

Filiaci, Virginia ^{[10
]}

Birrer, Michael J. ^{[11
]}

Leslie, Kimberly K. ^{[1
]}

机构：

[1] Univ Iowa, Holden Comprehens Canc Ctr, Dept Obstet & Gynecol, Iowa City, IA 52242 USA

[2] SUNY Univ Buffalo, Dept Biostat, Buffalo, NY USA

[3] Univ Iowa, Holden Comprehens Canc Ctr, Dept Pathol, Iowa City, IA 52242 USA

[4] Abington Mem Hosp, Dept Gynecol Oncol, Hanjani Inst Gynecol Oncol, Abington, PA 19001 USA

[5] Univ Colorado Denver, Dept Obstet & Gynecol, Aurora, CO USA

[6] Univ Calif Irvine, Med Ctr, Div Gynecol Oncol, Orange, CA USA

[7] Ohio State Univ, Med Ctr, Dept Div Obstet & Gynecol, Columbus, OH 43210 USA

[8] Nationwide Childrens Hosp, Res Inst, Dept Pathol, Columbus, OH USA

[9] Univ Chicago, Sect Med Oncol, Chicago, IL 60637 USA

[10] Roswell Pk Canc Inst, NRG Oncol, Gynecol Oncol Grp, Biostat & Data Ctr, Buffalo, NY 14263 USA

[11] Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02114 USA

来源：

GYNECOLOGIC ONCOLOGY | 2017年 / 146卷 / 02期

关键词：

PHASE-III TRIAL; OVEREXPRESSION; CARCINOMA; CHEMOTHERAPY; PROGNOSIS; PROLIFERATION; METASTASIS; MIGRATION; SUGGESTS; TUMORS;

D O I：

10.1016/j.ygyno.2017.05.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. Gynecologic Oncology Group (GOG) 177 demonstrated that addition of paclitaxel to a backbone of adriamycin/cisplatin improves overall survival (OS) and progression-free survival (PFS) for patients with advanced or recurrent endometrial cancer. Using patient specimens from GOG-177, our objective was to identify potential mechanisms underlying the improved clinical response to taxanes. Stathmin (STMN1) is a recognized poor prognostic marker in endometrial cancer that functions as a microtubule depolymerizing protein, allowing

引用

页码：247 / 253

页数：7

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