Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles

被引：48

作者：

Dao-Huy, Toan ^{[1
]}

Haider, Maximilian ^{[1
]}

Glatz, Fabian ^{[1
]}

Schnuerch, Michael ^{[1
]}

Mihovilovic, Marko D. ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, Getreidemarkt 9-163-OC, A-1060 Vienna, Austria

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 36期

基金：

奥地利科学基金会;

关键词：

Synthetic methods; Arylation; Fused-ring systems; C-H activation; Palladium; Regioselectivity; Concerted metal deprotonation; CATALYZED DIRECT ARYLATION; C-H FUNCTIONALIZATION; DIRECT C-2 ARYLATION; CROSS-COUPLING REACTIONS; BOND FORMATION; ONE-POT; 2,3-DISUBSTITUTED BENZOFURANS; ANTIINFLAMMATORY EVALUATION; HETEROAROMATIC-COMPOUNDS; OXIDATIVE CYCLIZATION;

D O I：

10.1002/ejoc.201403125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan.

引用

页码：8119 / 8125

页数：7

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