How Plastic Are Pericytes?

被引：55

作者：

Birbrair, Alexander ^{[1
,2
,3
]}

Borges, Isabella da Terra ^{[1
]}

Gilson Sena, Isadora Fernandes ^{[1
]}

Almeida, Gregorio Guilherme ^{[1
]}

Meirelles, Lindolfo da Silva ^{[4
]}

Goncalves, Ricardo ^{[1
]}

Mintz, Akiva ^{[5
]}

Delbono, Osvaldo ^{[6
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

[3] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10467 USA

[4] Univ Luterana Brasil, Lab Stem Cells & Tissue Engn, Canoas, Brazil

[5] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA

[6] Wake Forest Sch Med, Dept Internal Med Gerontol, Winston Salem, NC USA

来源：

STEM CELLS AND DEVELOPMENT | 2017年 / 26卷 / 14期

关键词：

pericytes; stem cells; regeneration; plasticity; MESENCHYMAL STEM-CELLS; BRAIN-BARRIER INTEGRITY; CENTRAL-NERVOUS-SYSTEM; MICROVASCULAR PERICYTES; PERIVASCULAR CELLS; STROMAL CELLS; MAJOR SOURCE; LESION SCAR; GROWTH; TISSUE;

D O I：

10.1089/scd.2017.0044

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, a recent study shows that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity. This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.

引用

页码：1013 / 1019

页数：7

共 95 条

[1] Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult
Al Ahmad, Abraham
Taboada, Carole Buergi
Gassmann, Max
Ogunshola, Omolara O.
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (02) : 693 - 705
[2] Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, Annika
Genove, Guillem
Betsholtz, Christer
[J]. DEVELOPMENTAL CELL, 2011, 21 (02) : 193 - 215
[3] Pericytes regulate the blood-brain barrier
Armulik, Annika
Genove, Guillem
Mae, Maarja
Nisancioglu, Maya H.
Wallgard, Elisabet
Niaudet, Colin
He, Liqun
Norlin, Jenny
Lindblom, Per
Strittmatter, Karin
Johansson, Bengt R.
Betsholtz, Christer
[J]. NATURE, 2010, 468 (7323) : 557 - U231
[4] Differential cytokine contributions of perivascular haematopoietic stern cell niches
Asada, Noboru
Kunisaki, Yuya
Pierce, Halley
Wang, Zichen
Fernandez, Nicolas F.
Birbrair, Alexander
Ma'ayan, Avi
Frenette, Paul S.
[J]. NATURE CELL BIOLOGY, 2017, 19 (03) : 214 - 223
[5] Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver
Asahina, Kinji
Zhou, Bin
Pu, William T.
Tsukamoto, Hidekazu
[J]. HEPATOLOGY, 2011, 53 (03) : 983 - 995
[6] Balabanov R, 1999, J NEUROSCI RES, V55, P578, DOI 10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR5>3.0.CO
[7] 2-E
[8] CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2
Balabanov, R
Washington, R
Wagnerova, J
DoreDuffy, P
[J]. MICROVASCULAR RESEARCH, 1996, 52 (02) : 127 - 142
[9] Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages
Bechmann, I
Priller, J
Kovac, A
Böntert, M
Wehner, T
Klett, FF
Bohsung, J
Stuschke, M
Dirnagl, U
Nitsch, R
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (10) : 1651 - 1658
[10] Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
Bell, Robert D.
Winkler, Ethan A.
Sagare, Abhay P.
Singh, Itender
LaRue, Barb
Deane, Rashid
Zlokovic, Berislav V.
[J]. NEURON, 2010, 68 (03) : 409 - 427

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