How Plastic Are Pericytes?

被引：57
作者：
Birbrair, Alexander [1 ,2 ,3 ]
Borges, Isabella da Terra [1 ]
Gilson Sena, Isadora Fernandes [1 ]
Almeida, Gregorio Guilherme [1 ]
Meirelles, Lindolfo da Silva [4 ]
Goncalves, Ricardo [1 ]
Mintz, Akiva [5 ]
Delbono, Osvaldo [6 ]
机构：
[1] Univ Fed Minas Gerais, Dept Pathol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10467 USA
[4] Univ Luterana Brasil, Lab Stem Cells & Tissue Engn, Canoas, Brazil
[5] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA
[6] Wake Forest Sch Med, Dept Internal Med Gerontol, Winston Salem, NC USA
来源：
STEM CELLS AND DEVELOPMENT | 2017年 / 26卷 / 14期
关键词：
pericytes; stem cells; regeneration; plasticity; MESENCHYMAL STEM-CELLS; BRAIN-BARRIER INTEGRITY; CENTRAL-NERVOUS-SYSTEM; MICROVASCULAR PERICYTES; PERIVASCULAR CELLS; STROMAL CELLS; MAJOR SOURCE; LESION SCAR; GROWTH; TISSUE;
D O I：
10.1089/scd.2017.0044
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, a recent study shows that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity. This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.
引用
收藏
页码：1013 / 1019
页数：7
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