IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis

被引：36

作者：

Pawlik, Andrzej ^{[1
]}

Kotrych, Daniel ^{[2
]}

Malinowski, Damian ^{[1
,3
]}

Dziedziejko, Violetta ^{[4
]}

Czerewaty, Michal ^{[1
]}

Safranow, Krzysztof ^{[4
]}

机构：

[1] Pomeranian Med Univ, Dept Physiol, Powstancow Wlkp 72, PL-70111 Szczecin, Poland

[2] Pomeranian Med Univ, Dept Orthopaed Traumatol & Orthopaed Oncol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland

[3] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, Powstancow Wlkp 72, PL-70111 Szczecin, Poland

[4] Pomeranian Med Univ, Dept Biochem & Med Chem, Powstancow Wlkp 72, PL-70111 Szczecin, Poland

来源：

BMC MUSCULOSKELETAL DISORDERS | 2016年 / 17卷

关键词：

Cytokines; IL17A; IL17F; Polymorphism; Rheumatoid arthritis; COLLAGEN-INDUCED ARTHRITIS; NECROSIS-FACTOR-ALPHA; BONE EROSION; JOINT INFLAMMATION; TH17; CELLS; IL-17; INTERLEUKIN-17; EXPRESSION; CYTOKINES; SYNOVIOCYTES;

D O I：

10.1186/s12891-016-1064-1

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA. Methods: We examined 422 RA patients and 337 subjects as a control group. Single nucleotide polymorphism (SNP) in the IL17A (rs2275913) and IL17F (rs763780, rs11465553, rs2397084) genes were genotyped using TaqMan genotyping assays from Life Technologies Genomic. Results: There were no significant differences in distribution of IL17A and IL17F genotypes and alleles between RA patients and control group. There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis rheumatoid factor, erosive disease as well as extra-articular manifestations. Conclusions: The results of this study suggest, that IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of RA in a Polish population.

引用

页数：6

共 27 条

[1] 2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative [J].

Aletaha, Daniel ;

Neogi, Tuhina ;

Silman, Alan J. ;

Funovits, Julia ;

Felson, David T. ;

Bingham, Clifton O., III ;

Birnbaum, Neal S. ;

Burmester, Gerd R. ;

Bykerk, Vivian P. ;

Cohen, Marc D. ;

Combe, Bernard ;

Costenbader, Karen H. ;

Dougados, Maxime ;

Emery, Paul ;

Ferraccioli, Gianfranco ;

Hazes, Johanna M. W. ;

Hobbs, Kathryn ;

Huizinga, Tom W. J. ;

Kavanaugh, Arthur ;

Kay, Jonathan ;

Kvien, Tore K. ;

Laing, Timothy ;

Mease, Philip ;

Menard, Henri A. ;

Moreland, Larry W. ;

Naden, Raymond L. ;

Pincus, Theodore ;

Smolen, Josef S. ;

Stanislawska-Biernat, Ewa ;

Symmons, Deborah ;

Tak, Paul P. ;

Upchurch, Katherine S. ;

Vencovsky, Jiri ;

Wolfe, Frederick ;

Hawker, Gillian .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2569-2581

[2] Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis [J].

Azizi, Gholamreza ;

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2013, 16 (03) :243-253

[3] Th17: the third member of the effector T cell trilogy [J].

Bettelli, Estelle ;

Korn, Thomas ;

Kuchroo, Vijay K. .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) :652-657

[4] Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein [J].

Bush, KA ;

Farmer, KA ;

Walker, JS ;

Kirkham, BW .

ARTHRITIS AND RHEUMATISM, 2002, 46 (03) :802-805

[5]

Chabaud M, 1999, ARTHRITIS RHEUM-US, V42, P963, DOI 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO

[6]

2-E

[7] Structural basis of receptor sharing by interleukin 17 cytokines [J].

Ely, Lauren K. ;

Fischer, Suzanne ;

Garcia, K. Christopher .

NATURE IMMUNOLOGY, 2009, 10 (12) :1245-U3

[8] T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines [J].

Fossiez, F ;

Djossou, O ;

Chomarat, P ;

FloresRomo, L ;

AitYahia, S ;

Maat, C ;

Pin, JJ ;

Garrone, P ;

Garcia, E ;

Saeland, S ;

Blanchard, D ;

Gaillard, C ;

DasMahapatra, B ;

Rouvier, E ;

Golstein, P ;

Banchereau, J ;

Lebecque, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) :2593-2603

[9] Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis [J].

Furuya, Takefumi ;

Hakoda, Masayuki ;

Ichikawa, Naomi ;

Higami, Kenshi ;

Nanke, Yuki ;

Yago, Toru ;

Kamatani, Naoyuki ;

Kotake, Shigeru .

CLINICAL RHEUMATOLOGY, 2007, 26 (12) :2137-2141

[10]

Gaffen S, 2009, NAT REV IMMUNOL, V9, P1

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