A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision

被引：21
作者：
Bessler, Jessica B.
Reddy, Kirthi C.
Hayashi, Michiko
Hodgkin, Jonathan
Villeneuve, Anne M.
机构：
[1] Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
[3] Univ Oxford, Dept Biochem, Genet Unit, Oxford OX1 3QU, England
来源：
GENETICS | 2007年 / 175卷 / 04期
基金：
英国医学研究理事会;
关键词：
C-ELEGANS; GERM-LINE; GENETIC-ANALYSIS; CHROMOSOME SYNAPSIS; SIGNALING PATHWAY; CHIASMA FORMATION; CELL-INTERACTIONS; RECOMBINATION; PROPHASE; MUTANTS;
D O I：
10.1534/genetics.107.070987
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25 degrees) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15 degrees.
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页码：2029 / 2037
页数：9
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