Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study

被引:8
|
作者
De Cosmi, Valentina [1 ]
Mazzocchi, Alessandra [1 ]
D'Oria, Veronica [2 ]
Re, Alessandro [3 ]
Spolidoro, Giulia Carla Immacolata [1 ]
Milani, Gregorio P. [1 ,4 ]
Berti, Cristiana [4 ]
Scaglioni, Silvia [5 ]
Giavoli, Claudia [1 ,6 ]
Bergamaschi, Silvia [6 ]
Rodari, Giulia [6 ]
Profka, Eriselda [6 ]
Colombo, Roberto [3 ]
Agostoni, Carlo [1 ,7 ]
机构
[1] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Anestesia & Terapia Intens Donna Bambino, I-20122 Milan, Italy
[3] Serv Alimentaz Pediat ASST Rhodense POT Bollate, I-20024 Milan, Italy
[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Unit, I-20122 Milan, Italy
[5] Fdn IRCCS Ca Granda Osped Maggiore Polidin, Fdn Marchi Dept Pediat, I-20122 Milan, Italy
[6] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Endocrinol Unit, I-20122 Milan, Italy
[7] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Intermediate Care Unit, I-20122 Milan, Italy
关键词
fatty acids; obesity; vitamin D; vitamin D deficiency; DHA; dietary supplements; BETA-CELL FUNCTION; 25-HYDROXYVITAMIN D; SUBCLINICAL INFLAMMATION; OVERWEIGHT CHILDREN; D DEFICIENCY; FATTY-ACIDS; DIETARY; PROGRAM; TRIAL; RISK;
D O I
10.3390/nu14071397
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial
    Raygan, Fariba
    Ostadmohammadi, Vahidreza
    Bahmani, Fereshteh
    Asemi, Zatollah
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2018, 84 : 50 - 55
  • [22] Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Composition, and Inflammation in Vitamin D-Deficient Middle-Aged Women
    Fatemeh Kheyruri
    Javad Sarrafzadeh
    Agha Fatemeh Hosseini
    Behnaz Abiri
    Mohammadreza Vafa
    Biological Trace Element Research, 2021, 199 : 2523 - 2534
  • [23] Effect of vitamin D supplementation on microvascular reactivity in obese adolescents: A randomized controlled trial
    Vinet, Agnes
    Morrissey, Christopher
    Perez-Martin, Antonia
    Goncalves, Aurelie
    Raverdy, Cecile
    Masson, Delphine
    Gayrard, Sandrine
    Carrere, Myriam
    Landrier, Jean-Francois
    Amiot, Marie-Josephe
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021, 31 (08) : 2474 - 2483
  • [24] The Health Effects of Vitamin D and Probiotic Co-Supplementation: A Systematic Review of Randomized Controlled Trials
    Abboud, Myriam
    Rizk, Rana
    AlAnouti, Fatme
    Papandreou, Dimitrios
    Haidar, Suzan
    Mahboub, Nadine
    NUTRIENTS, 2021, 13 (01)
  • [25] Effect Of Vitamin D Supplementation In Treatment Of First Episode Psychosis: A Randomized Double Blind, Placebo Controlled Study
    Kishore, Satyam
    Das, Basudeb
    Kshitiz, Kshitiz Kumar
    INDIAN JOURNAL OF PSYCHIATRY, 2015, 57 (05) : S58 - S58
  • [26] The effect of different amounts of vitamin D supplementation on serum calcidiol, anthropometric status, and body composition in overweight or obese nursing women: a study protocol for a randomized placebo-controlled clinical trial
    Gerveieeha, Zohre
    Siassi, Fereydoun
    Qorbani, Mostafa
    Ziaeian, Farzaneh
    Sotoudeh, Gity
    TRIALS, 2019, 20 (01)
  • [27] Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Composition, and Inflammation in Vitamin D-Deficient Middle-Aged Women
    Kheyruri, Fatemeh
    Sarrafzadeh, Javad
    Hosseini, Agha Fatemeh
    Abiri, Behnaz
    Vafa, Mohammadreza
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2021, 199 (07) : 2523 - 2534
  • [28] Effects of calcium-vitamin D co-supplementation on metabolic profiles in vitamin D insufficient people with type 2 diabetes: a randomised controlled clinical trial
    Tabesh, Marjan
    Azadbakht, Leila
    Faghihimani, Elham
    Tabesh, Maryam
    Esmaillzadeh, Ahmad
    DIABETOLOGIA, 2014, 57 (10) : 2038 - 2047
  • [29] Effects of vitamin D-fortified oil intake versus vitamin D supplementation on vitamin D status and bone turnover factors: A double blind randomized clinical trial
    Ghasemifard, Negar
    Hassanzadeh-Rostami, Zahra
    Abbasi, Azam
    Naghavi, Amir Mohammad
    Faghih, Shiva
    CLINICAL NUTRITION ESPEN, 2022, 47 : 28 - 35
  • [30] Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial
    El Hajj, Cynthia
    Walrand, Stephane
    Helou, Mariana
    Yammine, Kaissar
    NUTRIENTS, 2020, 12 (07) : 1 - 12