Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study

被引:8
|
作者
De Cosmi, Valentina [1 ]
Mazzocchi, Alessandra [1 ]
D'Oria, Veronica [2 ]
Re, Alessandro [3 ]
Spolidoro, Giulia Carla Immacolata [1 ]
Milani, Gregorio P. [1 ,4 ]
Berti, Cristiana [4 ]
Scaglioni, Silvia [5 ]
Giavoli, Claudia [1 ,6 ]
Bergamaschi, Silvia [6 ]
Rodari, Giulia [6 ]
Profka, Eriselda [6 ]
Colombo, Roberto [3 ]
Agostoni, Carlo [1 ,7 ]
机构
[1] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Anestesia & Terapia Intens Donna Bambino, I-20122 Milan, Italy
[3] Serv Alimentaz Pediat ASST Rhodense POT Bollate, I-20024 Milan, Italy
[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Unit, I-20122 Milan, Italy
[5] Fdn IRCCS Ca Granda Osped Maggiore Polidin, Fdn Marchi Dept Pediat, I-20122 Milan, Italy
[6] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Endocrinol Unit, I-20122 Milan, Italy
[7] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Intermediate Care Unit, I-20122 Milan, Italy
关键词
fatty acids; obesity; vitamin D; vitamin D deficiency; DHA; dietary supplements; BETA-CELL FUNCTION; 25-HYDROXYVITAMIN D; SUBCLINICAL INFLAMMATION; OVERWEIGHT CHILDREN; D DEFICIENCY; FATTY-ACIDS; DIETARY; PROGRAM; TRIAL; RISK;
D O I
10.3390/nu14071397
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels.
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页数:12
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