O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans

被引：59
作者：
Ibrahim, ARS [1 ]
Galal, AM
Ahmed, MS
Mossa, GS
机构：
[1] Tanta Univ, Coll Pharm, Dept Pharmacognosy, Tanta 8130, Egypt
[2] Cairo Univ, Coll Pharm, Dept Pharmacognosy, Cairo 11562, Egypt
[3] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 02期
关键词：
7-methoxyflavanone; sulfation; Cunninghamella elegans; NMR; ESI-MS;
D O I：
10.1248/cpb.51.203
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4'-sulfate. C elegans also converted 5,3',4'-trihydroxy-7-methoxyflavanone into eriodictyol-4'-sulfate. Furthermore, incubation of 5,4'-dihydroxy-7,3'-dimethoxyflavanone with the same fungus gave homoeriodictyol (5,7,4'-trihydroxy-3'-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.
引用
收藏
页码：203 / 206
页数：4
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