SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition Comment

被引：13

作者：

Altmann, Daniel M. ^{[1
]}

Reynolds, Catherine J. ^{[2
]}

Boyton, Rosemary J. ^{[2
,3
,4
]}

机构：

[1] Imperial Coll London, Dept Immunol & Inflammat, London, England

[2] Imperial Coll London, Dept Infect Dis, London, England

[3] Royal Brompton Hosp, Lung Div, London, England

[4] Harefield Hosp, London, England

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 05期

基金：

英国医学研究理事会; 欧盟地平线“2020”;

关键词：

D O I：

10.1016/j.xcrm.2021.100286

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.

引用

页数：3

共 14 条

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