Progress towards a vaccine against Ebola to meet emergency medical countermeasure needs

被引：5
作者：
Wolfe, Daniel N. [1 ]
Zarrabian, Amanda G. [1 ]
Disbrow, Gary L. [1 ]
Espeland, Eric M. [1 ]
机构：
[1] HHS, ASPR, BARDA, Thomas P ONeill Fed Bldg FOBS,200 C St SW, Washington, DC 20024 USA
来源：
VACCINE | 2019年 / 37卷 / 48期
关键词：
Ebola; Filovirus; Vaccine; DOUBLE-BLIND; NONHUMAN-PRIMATES; RANDOMIZED-TRIAL; VIRUS DISEASE; SAFETY; IMMUNOGENICITY; PROTECTS; CHALLENGE; ADULTS;
D O I：
10.1016/j.vaccine.2017.10.111
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Ebola virus epidemic in West Africa proved to be the largest in the history of filovirus outbreaks, causing the World Health Organization to declare a public health emergency of international concern in August of 2014. In collaboration with domestic and international partners, the Biomedical Advanced Research and Development Authority (BARDA) initiated several vaccine development projects in support of the overall response efforts. The urgency associated with the epidemic triggered the clinical evaluation of lead vaccine candidates starting in late 2014. Here we will discuss development of the lead vaccine candidates for Ebola virus, specifically Zaire ebolavirus. Published by Elsevier Ltd.
引用
收藏
页码：7178 / 7182
页数：5
相关论文
共 30 条
  • [1] Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
    Agnandji, S. T.
    Huttner, A.
    Zinser, M. E.
    Njuguna, P.
    Dahlke, C.
    Fernandes, J. F.
    Yerly, S.
    Dayer, J. -A.
    Kraehling, V.
    Kasonta, R.
    Adegnika, A. A.
    Altfeld, M.
    Auderset, F.
    Bache, E. B.
    Biedenkopf, N.
    Borregaard, S.
    Brosnahan, J. S.
    Burrow, R.
    Combescure, C.
    Desmeules, J.
    Eickmann, M.
    Fehling, S. K.
    Finckh, A.
    Goncalves, A. R.
    Grobusch, M. P.
    Hooper, J.
    Jambrecina, A.
    Kabwende, A. L.
    Kaya, G.
    Kimani, D.
    Lell, B.
    Lemaitre, B.
    Lohse, A. W.
    Massinga-Loembe, M.
    Matthey, A.
    Mordmueller, B.
    Nolting, A.
    Ogwang, C.
    Ramharter, M.
    Schmidt-Chanasit, J.
    Schmiedel, S.
    Silvera, P.
    Stahl, F. R.
    Staines, H. M.
    Strecker, T.
    Stubbe, H. C.
    Tsofa, B.
    Zaki, S.
    Fast, P.
    Moorthy, V.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (17) : 1647 - 1660
  • [2] Ebola Virus Disease Cluster - Northern Sierra Leone, January 2016
    Alpren, Charles
    Sloan, Michelle
    Boegler, Karen A.
    Martin, Daniel W.
    Ervin, Elizabeth
    Washburn, Faith
    Rickert, Regan
    Singh, Tushar
    Redd, John T.
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2016, 65 (26): : 681 - 682
  • [3] [Anonymous], 2016, OUTBREAKS CHRONOLOGY
  • [4] Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study
    De Santis, Olga
    Audran, Regine
    Pothin, Emilie
    Warpelin-Decrausaz, Loane
    Vallotton, Laure
    Wuerzner, Gregoire
    Cochet, Camille
    Estoppey, Daniel
    Steiner-Monard, Viviane
    Lonchampt, Sophie
    Thieny, Anne-Christine
    Mayor, Carole
    Bailer, Robert T.
    Mbaya, Olivier Tshiani
    Zhou, Yan
    Ploquin, Aurelie
    Sullivan, Nancy J.
    Graham, Barney S.
    Roman, Francois
    De Ryck, Iris
    Ballou, W. Ripley
    Kieny, Marie Paule
    Moorthy, Vasee
    Spertini, Francois
    Genton, Blaise
    [J]. LANCET INFECTIOUS DISEASES, 2016, 16 (03) : 311 - 320
  • [5] Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days
    Diallo, Boubacar
    Sissoko, Daouda
    Loman, Nicholas J.
    Bah, Hadja Aissatou
    Bah, Hawa
    Worrell, Mary Claire
    Conde, Lya Saidou
    Sacko, Ramata
    Mesfin, Samuel
    Loua, Angelo
    Kalonda, Jacques Katomba
    Erondu, Ngozi A.
    Dahl, Benjamin A.
    Handrick, Susann
    Goodfellow, Ian
    Meredith, Luke W.
    Cotten, Matthew
    Jah, Umaru
    Wadoum, Raoul Emeric Guetiya
    Rollin, Pierre
    Magassouba, N'Faly
    Malvy, Denis
    Anglaret, Xavier
    Carroll, Miles W.
    Aylward, Raymond Bruce
    Djingarey, Mamoudou Harouna
    Diarra, Abdoulaye
    Formenty, Pierre
    Keita, Sakoba
    Guenther, Stephan
    Rambaut, Andrew
    Duraffour, Sophie
    [J]. CLINICAL INFECTIOUS DISEASES, 2016, 63 (10) : 1353 - 1356
  • [6] Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)
    Duerr, Ann
    Huang, Yunda
    Buchbinder, Susan
    Coombs, Robert W.
    Sanchez, Jorge
    del Rio, Carlos
    Casapia, Martin
    Santiago, Steven
    Gilbert, Peter
    Corey, Lawrence
    Robertson, Michael N.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (02) : 258 - 266
  • [7] A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA
    Ewer, K.
    Rampling, T.
    Venkatraman, N.
    Bowyer, G.
    Wright, D.
    Lambe, T.
    Imoukhuede, E. B.
    Payne, R.
    Fehling, S. K.
    Strecker, T.
    Biedenkopf, N.
    Kraehling, V.
    Tully, C. M.
    Edwards, N. J.
    Bentley, E. M.
    Samuel, D.
    Labbe, G.
    Jin, J.
    Gibani, M.
    Minhinnick, A.
    Wilkie, M.
    Poulton, I.
    Lella, N.
    Roberts, R.
    Hartnell, F.
    Bliss, C.
    Sierra-Davidson, K.
    Powlson, J.
    Berrie, E.
    Tedder, R.
    Roman, F.
    De Ryck, I.
    Nicosia, A.
    Sullivan, N. J.
    Stanley, D. A.
    Mbaya, O. T.
    Ledgerwood, J. E.
    Schwartz, R. M.
    Siani, L.
    Colloca, S.
    Folgori, A.
    Di Marco, S.
    Cortese, R.
    Wright, E.
    Becker, S.
    Graham, B. S.
    Koup, R. A.
    Levine, M. M.
    Volkmann, A.
    Chaplin, P.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (17) : 1635 - 1646
  • [8] Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses
    Garbutt, M
    Liebscher, R
    Wahl-Jensen, V
    Jones, S
    Möller, P
    Wagner, R
    Volchkov, V
    Klenk, HD
    Feldmann, H
    Ströher, U
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (10) : 5458 - 5465
  • [9] Recombinant Vesicular Stomatitis Virus-Based Vaccines Against Ebola and Marburg Virus Infections
    Geisbert, Thomas W.
    Feldmann, Heinz
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2011, 204 : S1075 - S1081
  • [10] Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge
    Geisbert, Thomas W.
    Bailey, Michael
    Hensley, Lisa
    Asiedu, Clement
    Geisbert, Joan
    Stanley, Daphne
    Honko, Anna
    Johnson, Joshua
    Mulangu, Sabue
    Pau, Maria Grazia
    Custers, Jerome
    Vellinga, Jort
    Hendriks, Jenny
    Jahrling, Peter
    Roederer, Mario
    Goudsmit, Jaap
    Koup, Richard
    Sullivan, Nancy J.
    [J]. JOURNAL OF VIROLOGY, 2011, 85 (09) : 4222 - 4233
123