A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

被引：612
作者：
Wynn, RF
Hart, CA
Corradi-Perini, C
O'Neill, L
Evans, CA
Wraith, JE
Fairbairn, LJ
Bellantuono, I
机构：
[1] Royal Manchester Childrens Hosp, Stem Cell Res Grp, Manchester, Lancs, England
[2] Royal Manchester Childrens Hosp, Willink Biochem Genet Unit, Manchester, Lancs, England
[3] Canc Res UK Gene Therapy Grp, Paterson Inst Canc Res, Manchester, Lancs, England
[4] UMIST, Dept Biomol Sci, Leukemia Res Fund, Manchester, Lancs, England
来源：
BLOOD | 2004年 / 104卷 / 09期
关键词：
D O I：
10.1182/blood-2004-02-0526
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. (C) 2004 by The American Society of Hematology.
引用
收藏
页码：2643 / 2645
页数：3
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