Base sequence dependence of deoxyribonucleic acid studied by scanning tunneling microscopy

被引：14
作者：
Kanno, T
Tanaka, H
Miyoshi, N
Fukuda, M
Kawai, T
机构：
[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan
[2] Fukui Med Univ, Dept Pathol, Fukui 9101193, Japan
来源：
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS | 2000年 / 39卷 / 4A期
关键词：
DNA; scanning tunneling microscopy (STM); Cu(111); pulse injection; poly(dA-dT); poly(dG-dC);
D O I：
10.1143/JJAP.39.1892
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
In order to identify high-order structures and pitch length of deoxyribonucleic acid (DNA), poly(dA-dT).poly(dA-dT) and poly(dG-dC).poly(dG-dC) were adsorbed on Cu(111) substrates by the pulse injection method and were observed by ultra high vacuum (UHV) scanning tunneling microscopy (STM). In large-scale STM images, the high-order structure of poly(dC-dC)poly(dG-dC) has a higher divergence and shorter dimension compared with those of poly(dA-dT) poly(dA-dT). High-resolution STM images revealed that the pitch lengths of poly(dA-dT)poly(dA-dT) and poly(dG-dC)poly(dG-dC) adsorbed onto the surface were longer than those possessed in the aqueous solution.
引用
收藏
页码：1892 / 1893
页数：2
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