Ubiquitin and its kin: how close are the family ties?

被引：286

作者：

Jentsch, S ^{[1
]}

Pyrowolakis, G ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(00)01785-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Modification of proteins by the covalent attachment of ubiquitin is known to target them for degradation by proteasomes. Several proteins have been discovered recently that are related to ubiquitin or function similarly. Some of these proteins act as modifiers; others bear ubiquitin-like domains embedded in their polypeptide chain but do not form conjugates with cellular proteins. Ubiquitin-like proteins mediate an impressive range of cellular functions, including cell-cycle progression, DNA repair and apoptosis. Recent discoveries endorse the view that, in many cases, the function of the relatives of ubiquitin is linked to the ubiquitin pathway.

引用

页码：335 / 342

页数：8

共 60 条

[1]

ALKHODAIRY F, 1995, J CELL SCI, V108, P475

[2] Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center [J].

Biggins, S ;

Ivanovska, I ;

Rose, MD .

JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1331-1346

[3] SCF and cullin/RING H2-based ubiquitin ligases [J].

Deshaies, RJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :435-467

[4] SUMO-1 modification of IκBα inhibits NF-κB activation [J].

Desterro, JMP ;

Rodriguez, MS ;

Hay, RT .

MOLECULAR CELL, 1998, 2 (02) :233-239

[5] The Drosophila semushi mutation blocks nuclear import of Bicoid during embryogenesis [J].

Epps, JL ;

Tanda, S .

CURRENT BIOLOGY, 1998, 8 (23) :1277-1280

[6]

Everett RD, 1999, J CELL SCI, V112, P3443

[7] A surprising role for the proteasome in the regulation of herpesvirus infection [J].

Everett, RD .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (08) :293-295

[8] Identification of XDRP1;: a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation [J].

Funakoshi, M ;

Geley, S ;

Hunt, T ;

Nishimoto, T ;

Kobayashi, H .

EMBO JOURNAL, 1999, 18 (18) :5009-5018

[9] A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes [J].

Furukawa, K ;

Mizushima, N ;

Noda, T ;

Ohsumi, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (11) :7462-7465

[10] The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells [J].

Giorgino, F ;

de Robertis, O ;

Laviola, L ;

Montrone, C ;

Perrini, S ;

McCowen, KC ;

Smith, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1125-1130

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