Detection of a Single Nucleotide Polymorphism Using Single-Walled Carbon-Nanotube Near-Infrared Fluorescence

被引：31

作者：

Jeng, Esther S.

Nelson, John D.

Prather, Kristala L. J.

Strano, Michael S.

机构：

[1] Building 66-566, Cambridge, MA 02139-4307

来源：

SMALL | 2010年 / 6卷 / 01期

关键词：

carbon nanotubes; DNA; fluorescence detection; polymorphism; DNA CONFORMATIONAL POLYMORPHISM; GENOMIC DNA; IDENTIFICATION; DEPENDENCE;

D O I：

10.1002/smll.200900944

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The detection of a single nucleotide polymorphism (SNP) using single-walled carbon nanotube (SWNT) fluorescence is demonstrated for SWNTs coated in a probe DNA sequence via a fluorescenceenergy increase of only 0.8 meV upon addition of the complement containing a SNP. This mechanism Is simple, label- and enzyme-free, and the properties of the probe DNA that enable this detection are examined. (Figure Presented). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA,.

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页码：40 / 43

页数：4

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