Detection of a Single Nucleotide Polymorphism Using Single-Walled Carbon-Nanotube Near-Infrared Fluorescence

被引：31
作者：
Jeng, Esther S.
Nelson, John D.
Prather, Kristala L. J.
Strano, Michael S.
机构：
[1] Building 66-566, Cambridge, MA 02139-4307
来源：
SMALL | 2010年 / 6卷 / 01期
关键词：
carbon nanotubes; DNA; fluorescence detection; polymorphism; DNA CONFORMATIONAL POLYMORPHISM; GENOMIC DNA; IDENTIFICATION; DEPENDENCE;
D O I：
10.1002/smll.200900944
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The detection of a single nucleotide polymorphism (SNP) using single-walled carbon nanotube (SWNT) fluorescence is demonstrated for SWNTs coated in a probe DNA sequence via a fluorescenceenergy increase of only 0.8 meV upon addition of the complement containing a SNP. This mechanism Is simple, label- and enzyme-free, and the properties of the probe DNA that enable this detection are examined. (Figure Presented). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA,.
引用
收藏
页码：40 / 43
页数：4
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