Avoid Endoscopy in Children With Suspected Inflammatory Bowel Disease Who Have Normal Calprotectin Levels

被引：15

作者：

Heida, Anke ^{[1
]}

Holtman, Gea A. ^{[2
]}

Lisman-van Leeuwen, Yvonne ^{[2
]}

Berger, Marjolein Y. ^{[2
]}

van Rheenen, Patrick F. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Gastroenterol, Internal Code CA 80,POB 30001, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Gen Practice, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2016年 / 62卷 / 01期

关键词：

calprotectin; diagnostic yield; inflammatory bowel disease; S100A8/A9; FECAL CALPROTECTIN; METAANALYSIS;

D O I：

10.1097/MPG.0000000000000939

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In children with suspected inflammatory bowel disease, adding calprotectin stool testing to the screening strategy has been recommended to distinguish organic from nonorganic disease. In this cohort study with historical controls, we could not confirm that screening with stool calprotectin improves the diagnostic yield (ratio inflammatory bowel disease-positive endoscopies and total number of endoscopies); however, in patients with normal fecal calprotectin levels (<50 g/g) endoscopic and histological abnormalities were not seen. We propose to refrain from endoscopy when stool calprotectin levels are normal.

引用

页码：47 / 49

页数：3

共 9 条

[1] Fecal Calprotectin as a Correlative Marker in Clinical Severity of Infectious Diarrhea and Usefulness in Evaluating Bacterial or Viral Pathogens in Children [J].

Chen, Chien-Chang ;

Huang, Jing-Long ;

Chang, Chee-Jen ;

Kong, Man-Shan .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2012, 55 (05) :541-547

[2] Faecal Calprotectin in Suspected Paediatric Inflammatory Bowel Disease [J].

Degraeuwe, Pieter L. J. ;

Beld, Monique P. A. ;

Ashorn, Merja ;

Canani, Roberto Berni ;

Day, Andrew S. ;

Diamanti, Antonella ;

Fagerberg, Ulrika L. ;

Henderson, Paul ;

Kolho, Kaija-Leena ;

Van de Vijver, Els ;

van Rheenen, Patrick F. ;

Wilson, David C. ;

Kessels, Alfons G. H. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2015, 60 (03) :339-346

[3] Utility of faecal calprotectin in inflammatory bowel disease (IBD): what cut-offs should we apply? [J].

Dhaliwal, A. ;

Zeino, Z. ;

Tomkins, C. ;

Cheung, M. ;

Nwokolo, C. ;

Smith, S. ;

Harmston, C. ;

Arasaradnam, R. P. .

FRONTLINE GASTROENTEROLOGY, 2015, 6 (01) :14-19

[4]

Escher JC, 2005, J PEDIATR GASTR NUTR, V41, P1

[5] The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis [J].

Henderson, Paul ;

Anderson, Niall H. ;

Wilson, David C. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (05) :637-645

[6] Meta-analysis: Fecal Calprotectin for Assessment of Inflammatory Bowel Disease Activity [J].

Lin, Jin-Feng ;

Chen, Jin-Min ;

Zuo, Jun-Hua ;

Yu, Allen ;

Xiao, Zhu-Jun ;

Deng, Fei-Hong ;

Nie, Biao ;

Jiang, Bo .

INFLAMMATORY BOWEL DISEASES, 2014, 20 (08) :1407-1415

[7] Fecal calprotectin in healthy children [J].

Oord, Tonje ;

Hornung, Nete .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2014, 74 (03) :254-258

[8]

Rugtveit J, 2002, J PEDIATR GASTR NUTR, V34, P323, DOI 10.1097/00005176-200203000-00022

[9] Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis [J].

van Rheenen, Patrick F. ;

Van de Vijver, Els ;

Fidler, Vaclav .

BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 :188

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