More than fetal urine: enteral uptake of amniotic fluid as a major predictor for fetal growth during late gestation

被引：14

作者：

Bagci, Soyhan ^{[1
]}

Brosens, Erwin ^{[2
]}

Tibboel, Dick ^{[3
]}

De Klein, Annelies ^{[2
]}

Ijsselstijn, Hanneke ^{[3
]}

Wijers, Charlotte H. W. ^{[4
]}

Roeleveld, Nel ^{[4
]}

de Blaauw, Ivo ^{[5
]}

Broens, Paul M. ^{[6
,7
]}

van Rooij, Iris A. L. M. ^{[4
]}

Hoelscher, Alice ^{[8
]}

Boemers, Thomas M. ^{[8
]}

Pauly, Marcus ^{[9
]}

Muensterer, Oliver J. ^{[10
]}

Schmiedeke, Eberhard ^{[11
]}

Schaefer, Mattias ^{[12
]}

Ure, Benno E. ^{[13
,14
]}

Lacher, Martin ^{[13
,14
]}

Choinitzki, Vera ^{[15
]}

Schumacher, Johannes ^{[15
]}

Zwink, Nadine ^{[16
]}

Jenetzky, Ekkehart ^{[16
,17
]}

Katzer, David ^{[1
]}

Arand, Joerg ^{[18
]}

Bartmann, Peter ^{[1
]}

Reutter, Heiko M. ^{[1
,15
]}

机构：

[1] Univ Bonn, Childrens Hosp, Dept Neonatol & Pediat Intens Care, Adenauerallee 119, D-53113 Bonn, Germany

[2] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[3] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Pediat Surg & Intens Care, Rotterdam, Netherlands

[4] Radboudumc, Radboud Inst Hlth Sci, Dept Hlth Evidence, Nijmegen, Netherlands

[5] Radboudumc Amalia Childrens Hosp, Dept Surg Pediat Surg, Nijmegen, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Anorectal Physiol Lab, Groningen, Netherlands

[7] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Div Pediat Surg, Groningen, Netherlands

[8] Univ Hosp Cologne, Dept Pediat Surg & Urol, Cologne, Germany

[9] Asklepios Childrens Hosp St Augustin, Dept Pediat Surg, St Augustin, Germany

[10] Univ Med Mainz, Dept Pediat Surg, Mainz, Germany

[11] Klinikum Bremen Mitte, Ctr Child & Youth Hlth, Dept Pediat Surg & Urol, Bremen, Germany

[12] Cnopfsche Kinderklin, Dept Pediat Surg & Urol, Nurnberg, Germany

[13] Hannover Med Sch, Ctr Pediat Surg Hannover, Hannover, Germany

[14] Bult Childrens Hosp, Hannover, Germany

[15] Univ Bonn, Inst Human Genet, Bonn, Germany

[16] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[17] Johannes Gutenberg Univ Mainz, Dept Child & Adolescent Psychiat & Psychotherapy, D-55122 Mainz, Germany

[18] Univ Tubingen, Univ Childrens Hosp Tubingen, Dept Neonatol, Tubingen, Germany

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2016年 / 175卷 / 06期

关键词：

Fetal growth; Amniotic fluid; Fetal nutrition; Esophageal atresia; Small for gestational age; BIOCHEMICAL-COMPOSITION; ESOPHAGEAL LIGATION; MATERNAL SERUM; PREGNANCY; PROTEIN; CLASSIFICATION; RETARDATION; NUTRITION; TURNOVER; VOLUME;

D O I：

10.1007/s00431-016-2713-y

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The purpose of our study was to investigate the importance of amniotic fluid (AF) for fetal growth during late gestation using esophageal atresia (EA) patients as a model. In this retrospective cohort study, we compared the z-scores adapted for birth weights (BW z-scores) for each of 517 European newborns with congenital pre-gastric intestinal atresia, i.e., EA, to a European reference population. To account for the influence of the intestinal atresia on fetal growth per se, we compared adapted birth weights for each of 504 European newborns with post colonic intestinal atresia (anorectal malformation (ARM) with atresia of the anus) to the same European reference population. Analysis of the complete cohort showed (i) a significantly higher rate of small for gestational age newborns among EA compared to ARM newborns (p < 0.001) and (ii) significantly lower BW z-scores among EA compared to ARM newborns (p < 0.001). BW z-scores of EA newborns were significantly lower in term compared to preterm newborns with an inverse correlation with gestational age (GA) (Spearman correlation coefficient, r = -0.185, p < 0.001). Conclusions: Enteral uptake of AF seems to play a pivotal role in fetal growth during late gestation.

引用

页码：825 / 831

页数：7

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