Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: a systematic review and meta-analysis

被引：22

作者：

Riaz, Irbaz Bin ^{[1
]}

Zahid, Umar ^{[1
]}

Kamal, Muhammad Umar ^{[2
]}

Husnain, Muhammad ^{[1
]}

McBride, Ali ^{[3
]}

Hua, Anh ^{[4
]}

Hamadani, Auon Abbas ^{[1
]}

George, Laeth ^{[5
]}

Zeeshan, Ali ^{[6
]}

Sipra, Qurat-ul-Ain Riaz ^{[1
]}

Raina, Ammad ^{[7
]}

Rahman, Bushra ^{[5
]}

Puvvada, Soham ^{[1
]}

Anwer, Faiz ^{[1
]}

机构：

[1] Univ Arizona, Dept Med Hematol & Oncol, Tucson, AZ 85724 USA

[2] Icahn Sch Med Mt Sinai, Bronx Lebanon Hosp, Dept Med, Bronx, NY USA

[3] Univ Arizona, Coll Pharm, Tucson, AZ USA

[4] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85724 USA

[5] Univ Arizona, Coll Med, Phoenix, AZ 85004 USA

[6] Tucson Med Ctr, Dept Med, Tucson, AZ 85712 USA

[7] Canyon Vista Med Ctr, Dept Med, Sierra Vista, AZ 85635 USA

来源：

IMMUNOTHERAPY | 2017年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

chimeric antigen T cells; hematological malignancy; leukemia; lymphoma; refractory; relapse; ADOPTIVE IMMUNOTHERAPY; CLINICAL-TRIAL; RECEPTOR; LYMPHOMA; COSTIMULATION; MEMORY; PERSISTENCE; REMISSIONS; THERAPY; GRAFT;

D O I：

10.2217/imt-2017-0062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chimeric antigen receptor modified T cells targeting CD19 and CD20 have shown activity in Phase I, II trials of patients with hematological malignancies. We conducted a systematic review and meta-analysis of all published clinical trials studying the role of efficacy as well as safety of CD-19 and CD-20 chimeric antigen receptor-T therapy for B-cell hematologic malignancies. A total of 16 studies with 195 patients were identified. The pooled analysis showed an overall response rate of 61% (118/195) with complete response of 42% (81/195) and partial response of 19% (37/195). Major adverse events were cytokine release syndrome 33%, neurotoxicity 33% and B-cell aplasia 54%. Collectively, the results indicate encouraging response in relapsed/refractory B lymphoma and leukemia, especially in acute lymphoblastic leukemia (ALL) patients.

引用

页码：979 / 993

页数：15

共 49 条

[1] Donor origin CAR T cells: graft versus malignancy effect without GVHD, a systematic review [J].

Anwer, Faiz ;

Shaukat, Al-Aman ;

Zahid, Umar ;

Husnain, Muhammad ;

McBride, Ali ;

Persky, Daniel ;

Lim, Melissa ;

Hasan, Nida ;

Bin Riaz, Irbaz .

IMMUNOTHERAPY, 2017, 9 (02) :123-130

[2] Chimeric Antigen Receptor Therapy for Cancer [J].

Barrett, David M. ;

Singh, Nathan ;

Porter, David L. ;

Grupp, Stephan A. ;

June, Carl H. .

ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :333-347

[3] Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates [J].

Berger, Carolina ;

Jensen, Michael C. ;

Lansdorp, Peter M. ;

Gough, Mike ;

Elliott, Carole ;

Riddell, Stanley R. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :294-305

[4] Lymphodepletion and tumor burden govern clinical responses in patients with B-cell malignancies treated with autologous, CD19-targeted T cells. [J].

Brentjens, R. J. ;

Riviere, I. ;

Park, J. ;

Davilla, M. ;

Wang, X. ;

Yeh, R. ;

Lamanna, N. ;

Frattini, M. G. ;

Sadelain, M. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)

[5] CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia [J].

Brentjens, Renier J. ;

Davila, Marco L. ;

Riviere, Isabelle ;

Park, Jae ;

Wang, Xiuyan ;

Cowell, Lindsay G. ;

Bartido, Shirley ;

Stefanski, Jolanta ;

Taylor, Clare ;

Olszewska, Malgorzata ;

Borquez-Ojeda, Oriana ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Bernal, Yvette ;

Rijo, Ivelise V. ;

Hedvat, Cyrus ;

Kobos, Rachel ;

Curran, Kevin ;

Steinherz, Peter ;

Jurcic, Joseph ;

Rosenblat, Todd ;

Maslak, Peter ;

Frattini, Mark ;

Sadelain, Michel .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (177)

[6] Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias [J].

Brentjens, Renier J. ;

Riviere, Isabelle ;

Park, Jae H. ;

Davila, Marco L. ;

Wang, Xiuyan ;

Stefanski, Jolanta ;

Taylor, Clare ;

Yeh, Raymond ;

Bartido, Shirley ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Bernal, Yvette ;

Pegram, Hollie ;

Przybylowski, Mark ;

Hollyman, Daniel ;

Usachenko, Yelena ;

Pirraglia, Domenick ;

Hosey, James ;

Santos, Elmer ;

Halton, Elizabeth ;

Maslak, Peter ;

Scheinberg, David ;

Jurcic, Joseph ;

Heaney, Mark ;

Heller, Glenn ;

Frattini, Mark ;

Sadelain, Michel .

BLOOD, 2011, 118 (18) :4817-4828

[7] Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease [J].

Brudno, Jennifer N. ;

Somerville, Robert P. T. ;

Shi, Victoria ;

Rose, Jeremy J. ;

Halverson, David C. ;

Fowler, Daniel H. ;

Gea-Banacloche, Juan C. ;

Pavletic, Steven Z. ;

Hickstein, Dennis D. ;

Lu, Tangying L. ;

Feldman, Steven A. ;

Iwamoto, Alexander T. ;

Kurlander, Roger ;

Maric, Irina ;

Goy, Andre ;

Hansen, Brenna G. ;

Wilder, Jennifer S. ;

Blacklock-Schuver, Bazetta ;

Hakim, Frances T. ;

Rosenberg, Steven A. ;

Gress, Ronald E. ;

Kochenderfer, James N. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1112-+

[8] Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer [J].

Cartellieri, Marc ;

Bachmann, Michael ;

Feldmann, Anja ;

Bippes, Claudia ;

Stamova, Slava ;

Wehner, Rebekka ;

Temme, Achim ;

Schmitz, Marc .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[9] Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study [J].

Cruz, Conrad Russell Y. ;

Micklethwaite, Kenneth P. ;

Savoldo, Barbara ;

Ramos, Carlos A. ;

Lam, Sharon ;

Ku, Stephanie ;

Diouf, Oumar ;

Liu, Enli ;

Barrett, A. John ;

Ito, Sawa ;

Shpall, Elizabeth J. ;

Krance, Robert A. ;

Kamble, Rammurti T. ;

Carrum, George ;

Hosing, Chitra M. ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Grilley, Bambi J. ;

Heslop, Helen E. ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Bollard, Catherine M. ;

Dotti, Gianpietro .

BLOOD, 2013, 122 (17) :2965-2973

[10] Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia [J].

Dai, Hanren ;

Zhang, Wenying ;

Li, Xiaolei ;

Han, Qingwang ;

Guo, Yelei ;

Zhang, Yajing ;

Wang, Yao ;

Wang, Chunmeng ;

Shi, Fengxia ;

Zhang, Yan ;

Chen, Meixia ;

Feng, Kaichao ;

Wang, Quanshun ;

Zhu, Hongli ;

Fu, Xiaobing ;

Li, Suxia ;

Han, Weidong .

ONCOIMMUNOLOGY, 2015, 4 (11)

← 1 2 3 4 5 →