Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma

被引：5

作者：

Mouchet, Nicolas ^{[1
]}

Coquart, Nolwenn ^{[2
,3
]}

Lebonvallet, Nicolas ^{[2
]}

Le Gall-Ianotto, Christelle ^{[2
]}

Mogha, Ariane ^{[1
]}

Fautrel, Alain ^{[4
]}

Boulais, Nicholas ^{[2
]}

Dreno, Brigitte ^{[5
]}

Martin, Ludovic ^{[6
]}

Hu, Weiguo ^{[7
]}

Galibert, Marie-Dominique ^{[1
]}

Misery, Laurent ^{[2
,3
]}

机构：

[1] Univ Rennes 1, CNRS, Genet & Dev Inst Rennes, UMR6290, Rennes, France

[2] Univ Western Brittany, Lab Neurosci Brest EA4685, Brest, France

[3] Univ Hosp Brest, Dept Dermatol, Brest, France

[4] Univ Rennes 1, Histopathol Platform, Rennes, France

[5] Univ Hosp Nantes, Dept Dermatol, Nantes, France

[6] Univ Hosp Angers, Dept Dermatol, Angers, France

[7] Univ Hosp Brest, Dept Plast Surg, Brest, France

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 12期

关键词：

carcinoma; Merkel cell; microarray; microdissection; polyomavirus; POLYOMAVIRUS;

D O I：

10.1111/exd.12546

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPy-negative and MCPy-positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.

引用

页码：928 / 930

页数：3

共 50 条

[21] Merkel cell carcinoma
Fried, I.
Cerroni, L.
PATHOLOGE, 2014, 35 (05): : 467 - 475
[22] Merkel cell carcinoma
Wosnitza, M.
Bozkurt, A.
O'Dey, D.
Pallua, N.
Megahed, M.
HAUTARZT, 2009, 60 (05): : 366 - +
[23] Merkel cell carcinoma
NYRUD, M. O. R. T. E. N. K. R. I. S. T. O. F. F. E. R.
BRATLAND, A. S. E.
LANDRO, L. I. N. N.
BREVIG, T. R. I. N. E.
RYDER, T. R. U. L. S.
HERMANN, R. O. B. E. R. T.
FRICH, L. A. R. S.
TIDSSKRIFT FOR DEN NORSKE LAEGEFORENING, 2022, 142 (09) : 782 - 786
[24] Merkel Cell Carcinoma
Wong, Hannah H.
Wang, Jun
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2010, 134 (11) : 1711 - 1716
[25] Merkel cell carcinoma
Cheung, DSM
McInnes, IE
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1998, 68 (08): : 622 - 624
[26] Are there multiple cells of origin of Merkel cell carcinoma?
Sunshine, J. C.
Jahchan, N. S.
Sage, J.
Choi, J.
ONCOGENE, 2018, 37 (11) : 1409 - 1416
[27] Comparative In Vitro and In Vivo Studies on Feline, Canine, and Human Merkel Cell Carcinoma
Ito, Soma
Chambers, James K.
Mori, Chikako
Sumi, Ayumi
Omachi, Tetsuo
Nakayama, Hiroyuki
Uchida, Kazuyuki
VETERINARY PATHOLOGY, 2021, 58 (02) : 276 - 287
[28] Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia?
McFalls, Jeanne
Okon, Lauren
Cannon, Sarah
Lee, Jason B.
JOURNAL OF CUTANEOUS PATHOLOGY, 2017, 44 (05) : 480 - 485
[29] Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?
Lawrence, Lauren E. B.
Saleem, Atif
Sahoo, Malaya K.
Tan, Susanna K.
Pinsky, Benjamin A.
Natkunam, Yasodha
Kunder, Christian A.
Stehr, Henning
Zehnder, James L.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 154 (03) : 369 - 380
[30] Merkel cell carcinoma of the auricle
J. Virtaniemi
Pasi Hirvikoski
Matti Pukkila
Eero Kumpulainen
Risto Johansson
Veli-Matti Kosma
European Archives of Oto-Rhino-Laryngology, 2000, 257 : 558 - 560

← 1 2 3 4 5 →