Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma

被引：5

作者：

Mouchet, Nicolas ^{[1
]}

Coquart, Nolwenn ^{[2
,3
]}

Lebonvallet, Nicolas ^{[2
]}

Le Gall-Ianotto, Christelle ^{[2
]}

Mogha, Ariane ^{[1
]}

Fautrel, Alain ^{[4
]}

Boulais, Nicholas ^{[2
]}

Dreno, Brigitte ^{[5
]}

Martin, Ludovic ^{[6
]}

Hu, Weiguo ^{[7
]}

Galibert, Marie-Dominique ^{[1
]}

Misery, Laurent ^{[2
,3
]}

机构：

[1] Univ Rennes 1, CNRS, Genet & Dev Inst Rennes, UMR6290, Rennes, France

[2] Univ Western Brittany, Lab Neurosci Brest EA4685, Brest, France

[3] Univ Hosp Brest, Dept Dermatol, Brest, France

[4] Univ Rennes 1, Histopathol Platform, Rennes, France

[5] Univ Hosp Nantes, Dept Dermatol, Nantes, France

[6] Univ Hosp Angers, Dept Dermatol, Angers, France

[7] Univ Hosp Brest, Dept Plast Surg, Brest, France

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 12期

关键词：

carcinoma; Merkel cell; microarray; microdissection; polyomavirus; POLYOMAVIRUS;

D O I：

10.1111/exd.12546

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPy-negative and MCPy-positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.

引用

页码：928 / 930

页数：3

共 12 条

[1] Immunohistochemical Features of Merkel Cell Carcinoma in Correlation with Presence of Merkel Cell Polyomavirus DNA [J].

Andres, Christian ;

Belloni, Benedetta ;

Jaeger, Teresa ;

Puchta, Ursula ;

Konstantinow, Alexander ;

Ring, Johannes ;

Flaig, Michael Josef .

ACTA DERMATO-VENEREOLOGICA, 2011, 91 (06) :722-723

[2] Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma [J].

Asplund, A. ;

Bjorklund, M. Gry ;

Sundquist, C. ;

Stromberg, S. ;

Edlund, K. ;

Oestman, A. ;

Nilsson, P. ;

Ponten, F. ;

Lundeberg, J. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 158 (03) :527-538

[3] Merkel cells [J].

Boulais, Nicholas ;

Misery, Laurent .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 57 (01) :147-165

[4] Merkel Cells as Putative Regulatory Cells in Skin Disorders: An In Vitro Study [J].

Boulais, Nicholas ;

Pereira, Ulysse ;

Lebonvallet, Nicolas ;

Gobin, Eric ;

Dorange, Germaine ;

Rougier, Nathalie ;

Chesne, Christophe ;

Misery, Laurent .

PLOS ONE, 2009, 4 (08)

[5]

Feng HC, 2008, SCIENCE, V319, P1096, DOI 10.1126/science.1152586

[6] Distinct Gene Expression Profiles of Viral- and Nonviral-Associated Merkel Cell Carcinoma Revealed by Transcriptome Analysis [J].

Harms, Paul W. ;

Patel, Rajiv M. ;

Verhaegen, Monique E. ;

Giordano, Thomas J. ;

Nash, Kevin T. ;

Johnson, Craig N. ;

Daignault, Stephanie ;

Thomas, Dafydd G. ;

Gudjonsson, Johann E. ;

Elder, James T. ;

Dlugosz, Andrzej A. ;

Johnson, Timothy M. ;

Fullen, Douglas R. ;

Bichakjian, Christopher K. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 (04) :936-945

[7] Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources [J].

Huang, Da Wei ;

Sherman, Brad T. ;

Lempicki, Richard A. .

NATURE PROTOCOLS, 2009, 4 (01) :44-57

[8] Recent advances in the biology of Merkel cell carcinoma [J].

Kuwamoto, Satoshi .

HUMAN PATHOLOGY, 2011, 42 (08) :1063-1077

[9] Presence of putative stem cells in Merkel cell carcinomas [J].

Lemasson, G. ;

Coquart, N. ;

Lebonvallet, N. ;

Boulais, N. ;

Galibert, M. D. ;

Marcorelles, P. ;

Misery, L. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2012, 26 (06)

[10] Merkel Cell Polyomavirus Small T Antigen mRNA Level Is Increased following In Vivo UV-Radiation [J].

Mogha, Ariane ;

Fautrel, Alain ;

Mouchet, Nicolas ;

Guo, Na ;

Corre, Sebastien ;

Adamski, Henri ;

Watier, Eric ;

Misery, Laurent ;

Galibert, Marie-Dominique .

PLOS ONE, 2010, 5 (07)

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