Selective aggregation of membrane proteins by membrane-mediated interactions

被引：5

作者：

Li ShuangYang ^{[1
,2
]}

Zhang XianRen ^{[2
]}

Wang WenChuan ^{[2
]}

机构：

[1] Beijing Technol & Business Univ, Sch Food & Chem Engn, Beijing 100048, Peoples R China

[2] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2014年 / 57卷 / 12期

基金：

中国国家自然科学基金;

关键词：

selective aggregation; anchored protein; transmembrane protein; dissipative particle dynamics (DPD); COMPUTER-SIMULATIONS; PLASMA-MEMBRANE; LIPID-BILAYERS; CURVATURE; FUSION; MODEL;

D O I：

10.1007/s11426-014-5227-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

There are different types of membrane proteins in a cellular membrane, and most of them must correctly assemble into appropriate clusters for their cellular functions. In this work, we suggest a physical mechanism for selective aggregation of different membrane proteins without specific protein-protein attraction by dissipative particle dynamics method. A membrane-mediated interaction may result in different protein clusters with ideal mixing, nonideal mixing and demixing of different types of membrane proteins, depending on the extent of the similarity of membrane deformations by those proteins.

引用

页码：1683 / 1689

页数：7

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