Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis

被引：22

作者：

Di Giacomo, Roberta ^{[1
]}

Deleo, Francesco ^{[1
]}

Pastori, Chiara ^{[1
]}

Didato, Giuseppe ^{[1
]}

Andreetta, Francesca ^{[2
]}

Del Sole, Angelo ^{[3
]}

de Curtis, Marco ^{[1
]}

Villani, Flavio ^{[1
,4
]}

机构：

[1] Fdn IRCCS Ist Neurol Carlo Besta, Epilepsy Unit, Milan, Italy

[2] Fdn IRCCS Ist Neurol Carlo Besta, UO Neurol 4, Milan, Italy

[3] Univ Milan, Dept Hlth Sci, Nucl Med Unit, ASST Santi Paolo & Carlo, Milan, Italy

[4] Policlin IRCCS San Martino, Div Clin Neurophysiol, Genoa, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 337卷

关键词：

Anti-glutamic acid decarboxylase 65 antibody; Autoimmune encephalitis; Limbic encephalitis; Neuroimmunology; Immunotherapy; GLUTAMIC-ACID DECARBOXYLASE; CEREBELLAR GABAERGIC TRANSMISSION; AUTOANTIBODIES; INHIBITION;

D O I：

10.1016/j.jneuroim.2019.577063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic acid decarboxylase (anti-GAD65) antibodies (998,881 IU/ml and 54,687 IU/ml respectively). Limbic encephalitis was diagnosed and high dose steroids treatment started. During one-year follow-up, without further immunomodulatory therapy, the patient became seizure free, and cognitive functions returned to normal. Serum anti-GAD65 antibodies titer decreased significantly but remained elevated (192,680 IU/m1). We discuss the prognostic and pathogenic value of high titer anti-GAD65 antibodies and its variations in a case of autoimmune limbic encephalitis.

引用

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