Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1α inhibition

被引：65
作者：
Du, Gangjun [1 ,2 ]
Han, Guang [1 ]
Zhang, Shuo [1 ,2 ]
Lin, Haihong [1 ]
Wu, Xianchuang [1 ]
Wang, Mei [1 ]
Ji, Liyan [1 ]
Lu, Linlin [1 ]
Yu, Lijuan [1 ]
Liang, Wei [2 ]
机构：
[1] Henan Univ, Coll Pharm, Inst Pharm, Kaifeng 475001, Henan, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Prot & Peptide Pharmaceut Lab, Beijing 100101, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2010年 / 630卷 / 1-3期
基金：
中国国家自然科学基金;
关键词：
Baicalin; Lung carcinoma; Lung metastasis; SOD mimic; HIF-1; alpha; SUPEROXIDE-DISMUTASE; CANCER-CELLS; H2O2; RELEASE; HYPOXIA; OVEREXPRESSION; APOPTOSIS; GROWTH; HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA; DOXORUBICIN; ACTIVATION;
D O I：
10.1016/j.ejphar.2009.12.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The dose-related toxicity of anticancer drugs in chemotherapy of clinical carcinoma is the major obstacle to prolonged survival, we want to investigate selective therapeutic efficacy of baicalin oil lung carcinoma and explain the basis underlying this phenomenon In vitro, baicalin inhibited cell proliferation Of human lung carcinoma A549 and mouse lewis lung cancer (LLC) in a dose- and time-dependent manner The inhibitory activity of baicalin against cancer cells was promoted by superoxide dismutase (SOD) addition or hypoxia-inducible factor-1alpha (HIF-1 alpha) knockdown and was reduced by SOD knockdown but not hypoxia In vivo. baicalin suppressed tumor growth and prolonged Survival in C57BL/6 mice bearing LLC tumor and nude mice bearing A549 carcinoma without systemic toxicity Further studies showed that baicalin inhibited HIF-1 alpha and enhanced SOD activity without affecting catalase and glutathione-S-transferase (GST) in cancer cells In addition, baicalin also exhibited a superoxide anion scavenging activity In conclusion, baicalin could selectively suppress lung carcinoma and lung metastasis by SOD mimic and HIF-1 alpha inhibition (C) 2009 Elsevier B V All rights reserved
引用
收藏
页码：121 / 130
页数：10
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