Syntheses of amamistatin fragments and determination of their HDAC and antitumor activity

被引：35

作者：

Fennell, Kelley A. ^{[1
]}

Miller, Marvin J.

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[2] Univ Notre Dame, Walter Canc Ctr, Notre Dame, IN 46556 USA

[3] Hans Knoll Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 09期

关键词：

D O I：

10.1021/ol070382e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amamistatins A and B are natural products found to have anti-proliferative effects against MCF-7, A549, and MKN45 human tumor cell lines (IC(50) 0.24-0.56 mu M). It was proposed that their activity was due to histone deacetylase (HDAC) inhibition mediated by the N-formyl-N-hydroxy lysine moiety. Amamistatin B fragment analogs were synthesized and screened for biological activity. These compounds were modest HDAC inhibitors and showed antitumor activity against MCF-7 and PC-3 human tumor cells.

引用

页码：1683 / 1685

页数：3

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