Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

被引:10
作者
Perez-Campos Mayoral, Laura [1 ]
Teresa Hernandez-Huerta, Maria [2 ]
Papy-Garcia, Dulce [3 ]
Barritault, Denis [3 ]
Zenteno, Edgar [4 ]
Sanchez Navarro, Luis Manuel [5 ]
Perez-Campos Mayoral, Eduardo [1 ]
Matias Cervantes, Carlos Alberto [2 ]
Martinez Cruz, Margarito [6 ]
Mayoral Andrade, Gabriel [1 ]
Lopez Cervantes, Malaquias [4 ]
Vazquez Martinez, Gabriela [6 ]
Lopez Sanchez, Claudia [6 ]
Pina Canseco, Socorro [1 ]
Martinez Cruz, Ruth [1 ]
Perez-Campos, Eduardo [6 ,7 ]
机构
[1] Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Ctr Invest Fac Med UNAM UABJO, Oaxaca 68020, Oaxaca, Mexico
[2] Univ Autonoma Benito Juarez, CONACYT Fac Med & Cirugia, Oaxaca 68020, Oaxaca, Mexico
[3] Univ Paris Est Creteil, F-94000 Creteil, France
[4] Univ Nacl Autonoma Mexico, Fac Med, Ciudad De Mexico 04360, Mexico
[5] Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68020, Oaxaca, Mexico
[6] Tecnol Nacl Mexico Inst Tecnol Oaxaca, Oaxaca 68030, Oaxaca, Mexico
[7] Lab Patol Clin Eduardo Perez Ortega, Oaxaca 68000, Oaxaca, Mexico
关键词
COVID-19; Hypercoagulability; Platelet; Hyperaggregability; Immunothrombosis; SARS-CoV-2; SINGLE NUCLEOTIDE POLYMORPHISM; MANNOSE-BINDING LECTIN; TRYPANOSOMA-CRUZI; HEPARAN-SULFATE; SIALIC-ACID; SARS-COV-2; RECEPTOR; PREVALENCE; PLATELET; SULODEXIDE;
D O I
10.1007/s11010-021-04204-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.
引用
收藏
页码:3815 / 3825
页数:11
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