Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

被引：10

作者：

Perez-Campos Mayoral, Laura ^{[1
]}

Teresa Hernandez-Huerta, Maria ^{[2
]}

Papy-Garcia, Dulce ^{[3
]}

Barritault, Denis ^{[3
]}

Zenteno, Edgar ^{[4
]}

Sanchez Navarro, Luis Manuel ^{[5
]}

Perez-Campos Mayoral, Eduardo ^{[1
]}

Matias Cervantes, Carlos Alberto ^{[2
]}

Martinez Cruz, Margarito ^{[6
]}

Mayoral Andrade, Gabriel ^{[1
]}

Lopez Cervantes, Malaquias ^{[4
]}

Vazquez Martinez, Gabriela ^{[6
]}

Lopez Sanchez, Claudia ^{[6
]}

Pina Canseco, Socorro ^{[1
]}

Martinez Cruz, Ruth ^{[1
]}

Perez-Campos, Eduardo ^{[6
,7
]}

机构：

[1] Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Ctr Invest Fac Med UNAM UABJO, Oaxaca 68020, Oaxaca, Mexico

[2] Univ Autonoma Benito Juarez, CONACYT Fac Med & Cirugia, Oaxaca 68020, Oaxaca, Mexico

[3] Univ Paris Est Creteil, F-94000 Creteil, France

[4] Univ Nacl Autonoma Mexico, Fac Med, Ciudad De Mexico 04360, Mexico

[5] Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Oaxaca 68020, Oaxaca, Mexico

[6] Tecnol Nacl Mexico Inst Tecnol Oaxaca, Oaxaca 68030, Oaxaca, Mexico

[7] Lab Patol Clin Eduardo Perez Ortega, Oaxaca 68000, Oaxaca, Mexico

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 10期

关键词：

COVID-19; Hypercoagulability; Platelet; Hyperaggregability; Immunothrombosis; SARS-CoV-2; SINGLE NUCLEOTIDE POLYMORPHISM; MANNOSE-BINDING LECTIN; TRYPANOSOMA-CRUZI; HEPARAN-SULFATE; SIALIC-ACID; SARS-COV-2; RECEPTOR; PREVALENCE; PLATELET; SULODEXIDE;

D O I：

10.1007/s11010-021-04204-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.

引用

页码：3815 / 3825

页数：11

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