Cell-based immunotherapy in gynecologic malignancies

被引：1

作者：

Kamat, Kalika ^{[1
]}

Krishnan, Venkatesh ^{[1
]}

Berek, Jonathan S. ^{[1
]}

Dorigo, Oliver ^{[1
]}

机构：

[1] Stanford Univ, Dept Obstet & Gynecol, Stanford Womens Canc Ctr, Stanford Canc Inst,Div Gynecol Oncol,Sch Med, Stanford, CA USA

来源：

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | 2021年 / 33卷 / 01期

关键词：

chimeric antigen receptor T-cell therapy; gynecologic malignancies; immunotherapy; macrophage-based cell therapy; natural killer-cell-based therapy; tumor-infiltrating lymphocytes; TUMOR-INFILTRATING LYMPHOCYTES; NATURAL-KILLER-CELLS; I CLINICAL-TRIAL; T-CELLS; RECURRENT OVARIAN; METASTATIC MELANOMA; ADOPTIVE TRANSFER; CANCER; THERAPY; PHAGOCYTOSIS;

D O I：

10.1097/GCO.0000000000000676

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Purpose of review To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers. Recent findings Recent clinical trial results demonstrate safety and tolerability of different cell therapies in gynecological cancers. Novel approaches, such as harnessing the cells of the innate immune system are also under investigation in a phase I trial. Cell-based therapies are gaining widespread attention as evidenced by the increasing number of clinical trials encompassing both, innate and adaptive cells to target gynecological cancers. A majority of these therapeutic approaches are well tolerated and show promising results in early trials.

引用

页码：13 / 18

页数：6

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