CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts

被引：161
作者：
Yu, XF
Huang, YF
Collin-Osdoby, P
Osdoby, P
机构：
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
[2] St Louis Univ, Div Bone & Mineral Res, St Louis, MO 63103 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 12期
关键词：
osteoclasts; macrophage inflammatory protein-1 alpha; regulated on activation; normal T-cell expressed and secreted; monocyte chemoattractant protein-3; chemokine receptors;
D O I：
10.1359/JBMR.040910
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chemoattractants that recruit OC precursors to locally inflamed sites of resorption are not well known. A chemokine receptor, CCR1, was expressed in OC precursors and elevated in mature OCs, and its ligands promoted OC precursor recruitment, RANKL development, and OC motility. Cytokines induced OB release of such chemokines, which may therefore significantly contribute to inflammatory bone loss.
引用
收藏
页码：2065 / 2077
页数：13
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