Association between epicardial fat volume and fractional flow reserve: An analysis of the determination of fractional flow reserve (DeFACTO) study

Background: This study examines the relationship between epicardial fat volume (EFV) and lesion-specific ischemia by fractional flow reserve (FFR). Methods: In a study of 173 patients (63.0 +/- 8.3 years) undergoing FFR, EFV was determined using cardiac computed tomography. Relationships between EFV and FFR were assessed using multivariable linear and logistic regression. Results: Using multivariable linear and logistic regression, no association between EFV and FFR was observed [SE] = -0.001 [0.003], P = 0.6, OR [95% CI]: 1.02 [0.94-1.11], P = 0.64, respectively). Conclusion: In patients with suspected or known coronary artery disease undergoing invasive angiography, EFV was not associated with FFR.