Ruthenium(II)-Catalyzed C-H Bond [3+2] Annulation of N-Nitrosoanilines with Alkynes in Water

被引：14

作者：

Chen, Xun ^{[1
]}

Cui, Xue ^{[1
]}

Bai, Lili ^{[1
]}

Wang, Ying ^{[1
]}

Xie, Ying ^{[2
]}

Wang, Shuojin ^{[1
]}

Zhai, Ruirui ^{[1
]}

Zhao, Ke ^{[1
]}

Kong, Dulin ^{[1
]}

Li, Youbin ^{[1
]}

机构：

[1] Hainan Med Univ, Sch Pharm, Hainan Key Lab Res & Dev Trop Herbs, Haikou 571199, Hainan, Peoples R China

[2] Sichuan Univ Sci & Engn, Sch Chem & Environm Engn, Zigong 643000, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 12期

基金：

海南省自然科学基金; 中国国家自然科学基金;

关键词：

ruthenium; C-H activation; annulation; water; indoles; EFFICIENT SYNTHESIS; INDOLE SYNTHESIS; ORGANIC-SYNTHESIS; ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; AMIDATION; ACCESS; AGENTS;

D O I：

10.1002/ajoc.201900553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Ru-II-catalyzed C-H bond redox-neutral annulation of N-nitrosoanilines with alkynes by employing water as the solvent has been developed. This transformation provides an easy and robust protocol for the synthesis of indoles with a broad range of functional group tolerance and excellent regioselectivity.

引用

页码：2209 / 2212

页数：4

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