Neurophysiological correlates of alcohol-specific inhibition in alcohol use disorder and its association with craving and relapse

被引：13

作者：

Batschelet, Hallie M. ^{[1
,2
]}

Tschuemperlin, Raphaela M. ^{[1
,2
,3
]}

Moggi, Franz ^{[1
]}

Soravia, Leila M. ^{[1
,3
]}

Koenig, Thomas ^{[1
]}

Pfeifer, Philippe ^{[1
,4
]}

Roesner, Susanne ^{[5
]}

Keller, Anne ^{[5
]}

Stein, Maria ^{[1
,6
]}

机构：

[1] Univ Hosp Psychiat & Psychotherapy, Translat Res Ctr, Bolligenstr 111, CH-3000 Bern 60, Switzerland

[2] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland

[3] Clin Suedhang, Ctr Treatment Addict Disorders, Sudhang 1, CH-3038 Kirchlindach, Switzerland

[4] Psychiat Zentrum Munsingen, Hunzigenstr 1, CH-3110 Munsingen, Switzerland

[5] Forel Clin, Addict Treatment Ctr, Islikonerstr 5, CH-8548 Ellikon An Der Thur, Switzerland

[6] Univ Bern, Inst Psychol, Dept Clin Psychol & Psychotherapy, Fabrikstr 8, CH-3012 Bern, Switzerland

来源：

CLINICAL NEUROPHYSIOLOGY | 2021年 / 132卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

Inhibitory control; Event-Related Potentials; Go; NoGo task; Alcohol Use Disorder; Relapse; Craving; EVENT-RELATED POTENTIALS; RESPONSE-INHIBITION; CLINICAL-RELEVANCE; DEPENDENT PATIENTS; IMPULSIVITY; DRINKING; IMPAIRMENT; PREDICTORS; REFLECTS; HEALTH;

D O I：

10.1016/j.clinph.2021.02.389

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: This study investigates neurophysiological correlates of general and alcohol-specific inhibitory control in patients with Alcohol Use Disorder (AUD), focusing on its association with individual craving levels and with relapse at three-month follow-up. Methods: 59 abstinent AUD patients and 20 healthy controls performed a Go/NoGo task incorporating alcohol-related and neutral stimuli during 64-channel electroencephalography (EEG) recording, yielding four event-related potentials (ERP) per participant (NoGo-Alcohol, Go-Alcohol, NoGo-Neutral, Go Neutral). Whole-scalp randomization-based statistics assessed effects of the factors group (patients/controls or relapsers/abstainers), craving level, response type (NoGo/Go) and picture type (alcohol/neutral) on topography and signal strength of the ERP components N2 and P3. Results: No differences on group level were observed between patients and controls. However, analyses incorporating individual craving indicated that the topographic difference between alcohol-related and neutral NoGo-N2 components increased with craving. Moreover, topographic differences in the alcohol-related and neutral NoGo-P3 component allowed for differentiation between relapsers and abstainers. Conclusions: In alcohol-related contexts, the response inhibition conflict reflected in the NoGo-N2 seems enhanced in patients with high craving. The inhibition-sensitive NoGo-P3 varies in relapsers but not in abstainers between neutral and alcohol-related contexts. Significance: In AUD patients, neurophysiological correlates of inhibition vary with alcohol-related contexts and craving, and might be indicative of relapse risk. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：1290 / 1301

页数：12

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