The delta opioid receptor: a novel therapeutic target for pain and even more ...

被引：0
作者：
Gaveriaux-Ruff, C. [1 ]
机构：
[1] Univ Strasbourg, Dept Neurobiol & Genet, INSERM, IGBMC,CNRS,UMR7104,U964, F-67400 Illkirch Graffenstaden, France
来源：
DOULEUR ET ANALGESIE | 2009年 / 22卷 / 04期
关键词：
Opioid receptor; Delta; Chronic pain; Anxiety depression; ANTIDEPRESSANT-LIKE ACTIVITIES; PROTEIN-COUPLED RECEPTORS; RAT MODEL; AGONIST SNC80; NEUROPATHIC PAIN; FUNCTIONAL COMPETENCE; ANTINOCICEPTIVE PROPERTIES; CHRONIC INFLAMMATION; MORPHINE-TOLERANCE; RHESUS-MONKEYS;
D O I：
10.1007/s11724-009-0146-3
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The delta opioid receptor is a novel target for pain treatment. The delta receptor appears different from the mu receptor as it is poorly effective for acute nociception but becomes more active in pathological situations. The interest for this receptor has increased recently with the identification of novel ligands and the study of its intracellular traffic. In addition, delta receptor activation lowers anxiety and depression. This review presents the recent knowledge on delta opioid analgesia and on the other neurobiological effects of delta receptor activation.
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收藏
页码：201 / 209
页数：9
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  • [1] Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5, 9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082)
    Aceto, Mario D.
    May, Everette L.
    Harris, Louis S.
    Bowman, Edward R.
    Cook, Charles D.
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 566 (1-3) : 88 - 93
  • [2] Molecular and neuroanatomical properties of the endogenous opioid system: Implications for treatment of opiate addiction
    Akil, H
    Meng, F
    Devine, DP
    Watson, SJ
    [J]. SEMINARS IN NEUROSCIENCE, 1997, 9 (3-4) : 70 - 83
  • [3] Effects of the local administration of selective μ-, δ- and κ-opioid receptor agonists on osteosarcoma-induced hyperalgesia
    Baamonde, A
    Lastra, A
    Juárez, L
    García, V
    Hidalgo, A
    Menéndez, L
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2005, 372 (03) : 213 - 219
  • [4] Opioids: Old drugs for potential new applications
    Barry, U
    Zuo, Z
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (10) : 1343 - 1350
  • [5] Sciatic nerve cuffing in mice: A model of sustained neuropathic pain
    Benbouzid, Malika
    Pallage, Viviane
    Rajalu, Mathieu
    Waltisperger, Elisabeth
    Doridot, Stephane
    Poisbeau, Pierrick
    Freund-Mercier, Marie Jose
    Barrot, Michel
    [J]. EUROPEAN JOURNAL OF PAIN, 2008, 12 (05) : 591 - 599
  • [6] Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia
    Benbouzid, Malika
    Gaveriaux-Ruff, Claire
    Yalcin, Ipek
    Waltisperger, Elisabeth
    Tessier, Luc-Henri
    Muller, Andre
    Kieffer, Brigitte L.
    Freund-Mercier, Marie Jose
    Barrot, Michel
    [J]. BIOLOGICAL PSYCHIATRY, 2008, 63 (06) : 633 - 636
  • [7] Trafficking of central opioid receptors and descending pain inhibition
    Bie, Bihua
    Pan, Zhizhong Z.
    [J]. MOLECULAR PAIN, 2007, 3
  • [8] Rewarding Morphine-Induced Synaptic Function of δ-Opioid Receptors on Central Glutamate Synapses
    Bie, Bihua
    Zhu, Wei
    Pan, Zhizhong Z.
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 329 (01) : 290 - 296
  • [9] Opioids and the skin - where do we stand?
    Bigliardi, Paul L.
    Tobin, Desmond J.
    Gaveriaux-Ruff, Claire
    Bigliardi-Qi, Mei
    [J]. EXPERIMENTAL DERMATOLOGY, 2009, 18 (05) : 424 - 430
  • [10] Associations of PTSD, chronic pain, and their comorbidity on cannabis use disorder: Results from an American nationally representative study
    Bilevicius, Elena
    Sommer, Ordana L.
    Asmundson, Gordon J. G.
    El-Gabalawy, Renee
    [J]. DEPRESSION AND ANXIETY, 2019, 36 (11) : 1036 - 1046
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