Comparative T2 and T1 mapping of patellofemoral cartilage under in situ mechanical loading with prospective motion correction

被引:25
作者
Lange, Thomas [1 ]
Knowles, Benjamin R. [1 ]
Herbst, Michael [1 ,2 ]
Izadpanah, Kaywan [3 ]
Zaitsev, Maxim [1 ]
机构
[1] Univ Freiburg, Dept Radiol, Med Phys, Med Ctr,Fac Med, Freiburg, Germany
[2] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA
[3] Univ Freiburg, Dept Orthoped & Trauma Surg, Fac Med, Med Ctr, Freiburg, Germany
基金
美国国家卫生研究院;
关键词
relaxation mapping; knee; cartilage; magnetic resonance imaging; prospective motion correction; in situ mechanical loading; ARTICULAR-CARTILAGE; RELAXATION-TIMES; T2; MRI; MECHANOBIOLOGY; OSTEOARTHRITIS; DEGENERATION; DEFORMATION; T1RHO;
D O I
10.1002/jmri.25574
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PurposeTo demonstrate improved T-2 and T-1 mapping of patellofemoral cartilage with in situ loading by means of prospective motion correction and to assess load-induced changes in healthy subjects. Materials and MethodsEstablished T-2 and T-1 mapping sequences were augmented with prospective motion correction based on optical tracking. Protocols were optimized for robust imaging of the patellofemoral cartilage at a field strength of 3T. Subjects were positioned in the scanner with knee flexion and in situ loading of the patellofemoral joint was performed with a pneumatic loading device. In a pilot study on a cohort of 10 healthy subjects, load-induced T-2 and T-1 changes were evaluated through measurements with axial loads of 0/20/40kg. ResultsWith prospective motion correction and additional lipid saturation, motion artifacts in patellofemoral cartilage magnetic resonance imaging (MRI) with in situ loading could be notably decreased, as demonstrated for T-2 mapping. The acquired relaxation maps suggested a T-2/T-1 decrease in superficial cartilage and a T-2/T-1 increase in deep cartilage under loading. However, in the quantitative group evaluation of the lateral patellar facet, only T-1 in superficial cartilage was significantly changed by loading (P 0.05), while no significant T-2 differences for the three loading conditions were observed (P 0.3). ConclusionProspective motion correction enables T-2 and T-1 mapping of patellofemoral cartilage with in situ loading and a comparison of the two contrasts in terms of their response to mechanical loading. T-1 is a more sensitive marker for load-induced patellar cartilage changes than T-2. Level of Evidence: 3 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:452-460
引用
收藏
页码:452 / 460
页数:9
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