Vinculin in cell-cell and cell-matrix adhesions

被引：338
作者：
Bays, Jennifer L. [1 ]
DeMali, Kris A. [1 ]
机构：
[1] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 16期
关键词：
Vinculin; Integrins; Cadherins; Cell adhesion; Cell migration; Force and mechanotransduction; COUPLING MEMBRANE PROTRUSION; ACTIN BUNDLE FORMATION; FOCAL-ADHESION; ALPHA-CATENIN; TYROSINE PHOSPHORYLATION; CONFORMATIONAL SWITCH; ADHERENS JUNCTION; CRYSTAL-STRUCTURE; BINDING PROTEIN; TRACTION FORCE;
D O I：
10.1007/s00018-017-2511-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
引用
收藏
页码：2999 / 3009
页数：11
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