Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans

被引：72

作者：

Borrajo-Calleja, Gustavo M. ^{[1
]}

Bizet, Vincent ^{[1
]}

Mazet, Clement ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

PHOSPHINE OXIDE LIGANDS; HECK REACTION; STEREOSELECTIVE-SYNTHESIS; CARBOAMINATION REACTIONS; EFFICIENT SYNTHESIS; COUPLING REACTIONS; MONO-OXIDATION; CHIRAL LIGAND; ALKENES; TETRAHYDROFURANS;

D O I：

10.1021/jacs.6b02158

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

引用

页码：4014 / 4017

页数：4

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