Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs

被引：26
作者：
Jiang, Siyang [1 ]
Lan, Shang [1 ]
Mao, Dake [1 ]
Yang, Xuan [1 ]
Shi, Kejia [1 ]
Ma, Da [1 ]
机构：
[1] Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 68期
基金：
中国国家自然科学基金;
关键词：
GENE DELIVERY; CANCER; PH; BIOACTIVITY; DISRUPTION; COMPLEXES; DEXTRAN; AGENTS;
D O I：
10.1039/c8cc05552a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report pro-guest and acyclic cucurbit[n]uril conjugated polymers as supramolecular drug delivery systems (DDSs). These supramolecular DDSs could encapsulate anti-tumor drugs. Under acidic conditions, an acid-labile pro-guest degraded to become a competing guest, which displaced and released the encapsulated drug at a tunable rate.
引用
收藏
页码：9486 / 9489
页数：4
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