Synthesis of permethylated α-D-mannosylacetic acid, a new type of bioconjugate

被引：8

作者：

Brunel, FM

Taylor, KG

Spatola, AF ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[2] Univ Louisville, Inst Mol Divers & Drug Design, Louisville, KY 40292 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(02)02770-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise stereoselective 3-step conversion of methyl alpha-D-mannopyranoside to alpha-D-2,3,4,6-tetra-O-methyl-mannosylacetic acid is described. After methylation of the alcohol functions, an allylation is performed. The resulting alkene undergoes oxidative cleavage to the acid, an alkylated C-sugar, appropriate for attachment to peptides or other drug candidates for solubility enhancement. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1287 / 1289

页数：3

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