Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC

被引：100
作者：
Seyer, Maria [1 ]
Kirchberger, Stefanie [1 ,2 ]
Majdic, Otto [1 ]
Seipelt, Joachim [3 ]
Jindra, Christoph [1 ]
Schrauf, Catharina [1 ]
Stoeckl, Johannes [1 ]
机构：
[1] Med Univ Vienna, Inst Immunol, A-1090 Vienna, Austria
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[3] Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1090 Vienna, Austria
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 02期
基金：
奥地利科学基金会;
关键词：
Human Rhinovirus; IL-35; Treg; REGULATORY T-CELLS; FOXP3; EXPRESSION; DENDRITIC CELLS; RECEPTOR; CYTOKINE; SUPPRESSION; IL-35; FORM;
D O I：
10.1002/eji.200939527
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-35 is a heterodimer of EBV-induced gene 3 and of the p35 subunit of IL-12, and recently identified as an inhibitory cytokine produced by natural Treg in mice, but not in humans. Here we demonstrate that DC activated by human rhinoviruses (R-DC) induce IL-35 production and release, as well as a suppressor function in CD4(+) and CD8(+) T cells derived from human peripheral blood but not in naive T cells from cord blood. The induction of IL-35-producing T cells by R-DC was FOXP3-independent, but blocking of B7-H1 (CD274) and sialoadhesin (CD169) on R-DC with mAb against both receptors prevented the induction of IL-35. Thus, the combinatorial signal delivered by R-DC to T cells via B7-H1 and sialoadhesin is crucial for the induction of human IL-35(+) Treg. These results demonstrate a novel pathway and its components for the induction of immune-inhibitory T cells.
引用
收藏
页码：321 / 329
页数：9
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