Cyclization of 4-hydroxy-3-hydroxyalkylcarbostyrils under mitsunobu conditions

被引：6

作者：

Coppola, GM ^{[1
]}

机构：

[1] Novartis Inst Biomed Res Inc, Dept Diabet & Metab, Cambridge, MA 02139 USA

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 18期

关键词：

cyclization; isatoic anhydride; mitsunabu; quinolones; sprioquinolones;

D O I：

10.1081/SCC-200030595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 4-hydroxy-3-hydroxyalkyl-1-methyl-2(1H)quinolinones with Ph3P/DEAD gives either C- or O-cyclized products depending on chain length. Hydroxyethyl produces only spiro cyclopropylquinolinone 6, whereas hydroxypropyl affords only pyranoquinolinone 8. Hydroxybutyl gives a 2:1 mixture of spiro cyclopentylquinolinone 11 and oxepinoquinolinone 10.

引用

页码：3381 / 3387

页数：7

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