Herpes Simplex Virus Type 2 Acquisition Among HIV-1-Infected Adults Treated With Tenofovir Disoproxyl Fumarate as Part of Combination Antiretroviral Therapy: Results From the ACTG A5175 PEARLS Study

被引：7

作者：

Celum, Connie ^{[1
,2
,3
]}

Hong, Ting ^{[1
]}

Cent, Anne ^{[4
]}

Donnell, Deborah ^{[1
,5
]}

Morrow, Rhoda ^{[4
,5
]}

Baeten, Jared M. ^{[1
,2
,3
]}

Firnhaber, Cynthia ^{[6
]}

Grinsztejn, Beatriz ^{[7
]}

Hosseinipour, Mina C. ^{[8
]}

Lalloo, Umesh ^{[9
]}

Nyirenda, Mulinda ^{[10
]}

Riviere, Cynthia ^{[11
]}

Sanchez, Jorge ^{[12
]}

Santos, Breno ^{[13
]}

Supparatpinyo, Khuanchai ^{[14
,15
]}

Hakim, James ^{[16
]}

Kumarasamy, N. ^{[17
]}

Campbell, Thomas B. ^{[18
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[5] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[6] Univ Witwatersrand, Fac Hlth Sci, Dept Med, Clin HIV Res Unit, Johannesburg, South Africa

[7] Fiocruz MS, Evandro Chagas Clin Res Inst, Rio De Janeiro, Brazil

[8] Kamuzu Cent Hosp, Lilongwe, Malawi

[9] Nelson R Mandela Sch Med, Durban, South Africa

[10] Coll Med, Dept Med, Blantyre, Malawi

[11] Inst Nacl Lab & Rech, Port Au Prince, Haiti

[12] Asociac Civil Impacta Salud & Educ, Lima, Peru

[13] Hosp Nossa Senhora Conceicao GHC, Serv Infectol, Porto Alegre, RS, Brazil

[14] Chiang Mai Univ, Dept Med, Chiang Mai, Thailand

[15] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand

[16] Univ Zimbabwe, Coll Hlth Sci, Harare, Zimbabwe

[17] YRG Ctr AIDS Res & Educ, Madras, Tamil Nadu, India

[18] Univ Colorado, Sch Med, Dept Med, Aurora, CO USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 06期

关键词：

HIV-1; HSV-2; prevention; tenofovir; antiretroviral therapy; Africa; HIV-1; TRANSMISSION; ORAL TENOFOVIR; PROPHYLAXIS; MEN;

D O I：

10.1093/infdis/jix029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective. Tenofovir disoproxyl fumarate (TDF) disoproxyl fumarate (TDF) has in vitro activity against herpes simplex virus type 2 (HSV-2) and reduced HSV-2 acquisition as preexposure prophylaxis. Whether TDF-containing antiretroviral therapy (ART) reduces HSV-2 acquisition is unknown. Design. Secondary analysis of AIDS Clinical Trials Group A5175, a randomized, open-label study of 3 ART regimens among 1571 participants. Methods. HSV-2 serostatus was assessed at baseline, at study exit, and before a change in ART regimen. Results. Of 365 HSV-2-seronegative persons, 68 acquired HSV-2, with 24 receiving TDF-containing ART and 44 receiving ART without TDF (HSV-2 seroconversion incidence, 6.42 and 6.63 cases/100 person-years, respectively; hazard ratio, 0.89; 95% confidence interval,.55-1.44). Conclusions. HSV-2 acquisition was not reduced in HIV-infected, HSV-2-uninfected persons during TDF-containing ART.

引用

页码：907 / 910

页数：4

共 7 条

[1] Herpes simplex virus type 2 (HSV-2) genital shedding in HSV-2-/HIV-1-co-infected women receiving effective combination antiretroviral therapy
Pere, Helene
Rascanu, Aida
LeGoff, Jerome
Matta, Mathieu
Bois, Frederic
Lortholary, Olivier
Leroy, Valeriane
Launay, Odile
Belec, Laurent
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Morrow, Rhoda A.
Donnell, Deborah
Hong, Ting
Hendrix, Craig W.
Thomas, Katherine K.
Fife, Kenneth H.
Nakku-Joloba, Edith
Mujugira, Andrew
Baeten, Jared M.
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Chohan, V.
Baeten, J. M.
Benki, S.
Graham, S. M.
Lavreys, L.
Mandaliya, K.
Ndinya-Achola, J. O.
Jaoko, W.
Overbaugh, J.
McClelland, R. S.
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[4] Herpes Simplex Virus Type-2 Cervicovaginal Shedding Among Women Living With HIV-1 and Receiving Antiretroviral Therapy in Burkina Faso: An 8-Year Longitudinal Study
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Nagot, Nicolas
Weiss, Helen A.
Konate, Issouf
Kania, Dramane
Segondy, Michel
Meda, Nicolas
van de Perre, Philippe
Mayaud, Philippe
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Devine, Angela
Foss, Anna M.
Delany-Moretlwe, Sinead
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[6] Impact of Acyclovir on Genital and Plasma HIV-1 RNA, Genital Herpes Simplex Virus Type 2 DNA, and Ulcer Healing among HIV-1-Infected African Women with Herpes Ulcers: A Randomized Placebo-Controlled Trial
Mayaud, Philippe
LeGoff, Jerome
Weiss, Helen A.
Gresenguet, Gerard
Nzambi, Khonde
Bouhlal, Hicham
Frost, Eric
Pepin, Jacques
Malkin, Jean-Elie
Hayes, Richard J.
Mabey, David C. W.
Belec, Laurent
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Post, Frank A.
Moyle, Graeme J.
Stellbrink, Hans Juergen
Domingo, Pere
Podzamczer, Daniel
Fisher, Martin
Norden, Anthony G.
Cavassini, Matthias
Rieger, Armin
Khuong-Josses, Marie-Aude
Branco, Teresa
Pearce, Helen C.
Givens, Naomi
Vavro, Cindy
Lim, Michael L.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 55 (01) : 49 - 57

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