Chemical Reactions Trigger Peptide Self-Assembly in vivo for Tumor Therapy

被引：11

作者：

Zeng, Xiang-Zhong ^{[1
,2
,3
]}

An, Hong-Wei ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

机构：

[1] Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci UCAS, Ctr Mat Sci & Optoelect Engn, 19 Yuquan Rd, Beijing 100049, Peoples R China

[3] Peking Univ, Acad Adv Interdisciplinary Studies, 5 Yiheyuan Rd, Beijing 100871, Peoples R China

来源：

CHEMMEDCHEM | 2021年 / 16卷 / 16期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

in  vivo self-assembly; nanomaterial; peptide; chemical reaction; tumor therapy; MORPHOLOGY TRANSFORMATION; POLYMERIC NANOPARTICLES; DRUG-DELIVERY; CANCER; NANOSTRUCTURES; NANOMATERIALS; MECHANISMS; NANOFIBERS; PLATFORM; HYPOXIA;

D O I：

10.1002/cmdc.202100254

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Self-assembly peptide materials have promoted the development of science research including life science, optics, medicine, and catalysis over the past two decades. Especially in tumor treatment, peptide self-assembly strategies have exhibited promising potential by their high degree of biocompatibility, construction modularization, and diversity in structure controllability. Driven by physical and chemical triggers, peptides can self-assemble in vivo to form fibers, spheres, hydrogels, or ribbons to achieve predeterminate biological functions. Peptide self-assembly triggered by chemical reactions provides superior specificity and intelligent responsiveness to produce assembly-induced biological effects in target regions. Herein, from the perspective of triggers of peptide assembly, we briefly review the applications of in vivo peptide self-assembly strategies for tumor treatment, including tumor-pathology-factor-induced chemical reactions and bio-orthogonal reactions

引用

页码：2452 / 2458

页数：7

共 66 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].