Origins, Biology, and Diseases of Tissue Macrophages

被引：91
作者：
Cox, Nehemiah [1 ]
Pokrovskii, Maria [1 ]
Vicario, Rocio [1 ]
Geissmann, Frederic [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Immunol, New York, NY 10065 USA
来源：
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 | 2021年 / 39卷
关键词：
tissue-resident macrophages; macrophage specification; tissue metabolism; genetic diseases; somatic mutations; STIMULATING FACTOR-I; BONE-MARROW-TRANSPLANTATION; CHEMOKINE RECEPTOR 2; HEREDITARY DIFFUSE LEUKOENCEPHALOPATHY; LANGERHANS CELL HISTIOCYTOSIS; ENDOTOXIN-INDUCED MEDIATOR; ERDHEIM-CHESTER DISEASE; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; APOPTOTIC CELLS;
D O I：
10.1146/annurev-immunol-093019-111748
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and multifunctional macrophage originating from hematopoietic stem cells; nor does it fit a pro- versus anti-inflammatory paradigm. This review presents and discusses current knowledge on the developmental biology of macrophages from an evolutionary perspective focused on the function of macrophages, which may aid in study of developmental, inflammatory, tumoral, and degenerative diseases. We also propose a framework to investigate the functions of macrophages in vivo and discuss how inherited germline and somatic mutations may contribute to the roles of macrophages in diseases.
引用
收藏
页码：313 / 344
页数：32
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